Developing the health state classification system for a condition-specific preference-based measure for patients with myasthenia gravis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36102606/
doi: 10.1080/09638288.2022.2120096. Online ahead of print. 1 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China. 2 JC School of Public Health and Primary Care,...
Conclusions: Based on a solid process of development and consultations with clinical professionals and patients, a valid MG-specific preference-based measure, MGQoL-6D, was developed. Further research will estimate the local preference weight to support the MG-related cost–utility analysis.
What are the pharmacotherapeutic considerations for the treatment of myasthenia gravis?
Source : https://www.tandfonline.com/doi/full/10.1080/14656566.2022.2122710
Myasthenia gravis (MG) is a rare neurological disorder characterized by the impairment of the normal neuromuscular transmission. The majority of patients display antibodies directed either against the acetylcholine receptor (AChR),...
Expert Opinion: The recent introduction and continuous investigation of novel drugs targeting different immunopathological mechanisms raise the expectation of finally changing the algorithm of immunosuppression in MG. There is in fact a great unmet need in MG for a more effective and better tolerated therapy which could relieve the double burden...
Metformin Inhibits the Pathogenic Functions of AChR-specific B and Th17 Cells by Targeting miR-146a
Source : https://www.sciencedirect.com/science/article/abs/pii/S0165247822001195?via=ihub
We established a classical animal model of myasthenia gravis as the experimental basis for the study of miR-146a. * We found that miR-146a expressed differently in thymus, lymph nodes and...
Conclusion/Relevance: We found that miR-146a expressed differently in thymus, lymph nodes and spleen of rat model, and the expression of mR-146a in disease specific T and B cells was also in a cell dependent manner. Pathological character of disease specific Th17 and B cells could be reversed by the metformin alternation of miR-146a levels in...
Pyridostigmine-induced coronary artery spasm in early-onset myasthenia gravis: a case presentation and review of the literature
Source : https://casereports.bmj.com/content/15/9/e249819
We present a case of pyridostigmine-induced coronary artery spasm in a woman with early-onset myasthenia gravis (MG) who suffered from acute chest discomfort a few days after pyridostigmine dose up-titration....
Relevance: We present a case of pyridostigmine-induced coronary artery spasm in a woman with early-onset myasthenia gravis (MG) who suffered from acute chest discomfort a few days after pyridostigmine dose up-titration. Twelve-lead ECG demonstrated ST-segment elevation in inferior limb leads together with sinus arrest.