Thrombotic Microangiopathy as a Life-Threatening Complication of Long-Term Interferon Beta Therapy for Multiple Sclerosis: Clinical Phenotype and Response to Treatment-A Literature Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38541824/
Thrombotic microangiopathy (TMA) has been observed in some patients receiving interferon beta (IFNβ) therapy for relapsing-remitting multiple sclerosis, but little is known about its clinical features and outcomes. We searched...
Thrombotic microangiopathy (TMA) in IFNβ-treated multiple sclerosis patients often presents with acute kidney injury, prodromal symptoms, and is treated with plasma exchange or eculizumab, improving renal outcomes in severe cases.
Comments on energy conservation treatments for MS-related fatigue and a new proposal - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38735103/
Psychological treatments of MS-related fatigue mostly depend on energy conservation programs. We argue that the evidence for energy conservation training is weak - in contrast to some reviews on this...
The authors critique energy conservation programs for MS-related fatigue and propose a three-step treatment approach, focusing on fatigue as a subjective feeling, using Progressive Muscle Relaxation to interrupt fatigue and improve treatment outcomes.
Therapeutic agents for steroid-refractory immune checkpoint inhibitor-related myocarditis: a narrative review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39263485/
The pathogenesis of steroid-refractory IRM and the treatment regimen remain unclear. A large number of studies need to be conducted to validate or update our proposed treatment approach.
Steroid-refractory immune checkpoint inhibitor-related myocarditis (IRM) management may involve abatacept, alemtuzumab, tocilizumab, or combination therapies tailored to specific comorbidities, with further research needed to refine treatment strategies.
Immune mediated myasthenia gravis in children, current concepts and new treatments: A narrative review article - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38988843/
Myasthenia gravis (MG) is the most frequent transmission disease in the neuromuscular junction. Juvenile myasthenia gravis (JMG) is an autoimmune antibody-mediated disease of postsynaptic endplate defined as MG presentation in...
Juvenile myasthenia gravis (JMG) is an autoimmune disease of the neuromuscular junction, presenting with fatigable weakness. Diagnosis involves clinical and antibody evaluation, while treatment includes immunosuppression and symptom management.
Sustained Response of Ibrutinib in a Patient with Waldenstrom Macroglobulinemia Presenting with Myasthenic Crisis as a Paraneoplastic Neurological Syndrome: A Case Report and Review of Literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39010768/
Paraneoplastic syndrome is a broad spectrum of signs and symptoms due to neoplasm, attributed to substances produced by tumor cells, or in response to it. Myasthenia gravis (MG) is a...
This case report highlights the effective use of Ibrutinib for treating Waldenstrom macroglobulinemia-associated myasthenia gravis, suggesting MG as a potential paraneoplastic syndrome of WM and Ibrutinib as a beneficial therapy.