Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference
Source : https://www.mdpi.com/2076-3425/11/2/234/htm
A neuronal dysfunction based on the imbalance between excitatory and inhibitory cortical-subcortical neurotransmission seems at the basis of migraine. Intercritical neuronal abnormal excitability can culminate in the bioelectrical phenomenon of...
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Huma Sheikh, CEO, NY Neurology Medicine, PC5yrIt will be interesting to see all the places where cGRP is incorporated and plays a role.
Sex dependent sensitivity to CGRP
Source : https://www.cgrpforum.org/authors/andrew-f-russo/
Recent studies reported by Dr Greg Dussor (University of Texas, Dallas) at the 2017 American Headache Society meeting in Boston, USA, have opened up an exciting new perspective on CGRP...
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Huma Sheikh, CEO, NY Neurology Medicine, PC5yrvery interesting, this opens up the field to test cGRP on men more specifically to see if this theory holds true.
Somatosensory Gating Responses Are Associated with Prognosis in Patients with Migraine
Source : https://www.mdpi.com/2076-3425/11/2/166
Sensory gating, a habituation-related but more basic protective mechanism against brain sensory overload, is altered in patients with migraine and linked to headache severity. This study investigated whether somatosensory (SI)...
A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine
Source : https://link.springer.com/article/10.1007/s12031-020-01788-1
Migraine is a common neurovascular condition. This disorder has a complex genetic background. Several single-nucleotide polymorphisms (SNPs) or mutations within genes regulating glutamatergic neurotransmission, cortical excitability, ion channels, and solute...
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Huma Sheikh, CEO, NY Neurology Medicine, PC5yrReally comprehensive review!
The impact of Pain-related emotions on migraine
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804193/
Migraine is one of the most common headache disorders, with a worldwide prevalence ranging from 5 to 12%. The World Health Organization (WHO) has recognized migraine as an urgent public...
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Huma Sheikh, CEO, NY Neurology Medicine, PC5yrI think anxiety and fear of pain play a great role in the prognosis of these patients long term. Many patients describe that the anxiety of their next attack is Show More