Association Between Hemostatic Profile and Migraine: A Mendelian Randomization Analysis
Source : https://n.neurology.org/content/early/2021/04/01/WNL.0000000000011931.abstract
Objective: To assess support for a causal relationship between hemostatic measures and migraine susceptibility using genetic instrumental analysis. Methods: Two-sample Mendelian randomization (MR) instrumental leveraging available genome-wide association study (GWAS)...
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Huma Sheikh, CEO, NY Neurology Medicine, PC5yrThis is the new wave of providing specific patient-centric treatment.
Abnormalities in cortical pattern of coherence in migraine detected using ultra high-density EEG
Source : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab061/6208887
Abstract. Individuals with migraine generally experience photophobia and/or phonophobia during and between migraine attacks. Many different mechanisms have been
52 yo F with a 36 year history of migraine. Has had good control with topiramate 100 mg daily and as needed treatment for breakthrough attacks with rizatriptan 10 mg. Recently diagnosed (in past month) with stable coronary artery disease. Cardiology recommends discontinuing the rizatriptan. She only needs to use the rizatriptan around 3 times per...
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Huma Sheikh, CEO, NY Neurology Medicine, PC5yrI agree with the above, a triptan may still be a viable option. The other suggestions above also make good sense, I tend to stay away from lasmitidan as Show More
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Heidi Schwarz, Professor of Clinical Neurology, URMC5yrI will start by saying that I am not sure she cannot continue with rizatriptan given her infrequent use and assuming she has no symptoms when using it. There Show More
Opening of ATP sensitive potassium channels causes migraine attacks with aura
Source : https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awab136/6188619
Abstract. Migraine afflicts more than one billion individuals worldwide and is a leading cause of years lived with disability. In about a third of individuals w
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Huma Sheikh, CEO, NY Neurology Medicine, PC5yrThis makes sense in regards to the cortical spreading depression.
Common variants in KCNK5 and FHL5 genes contributed to the susceptibility of migraine without aura in Han Chinese population
Source : https://www.nature.com/articles/s41598-021-86374-0
A recent genome-wide meta study suggested that rs67338227 in the FHL5 gene and rs10456100 in the KCNK5 gene are associated with migraine from 27 population-based cohorts excluding Chinese population.
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Huma Sheikh, CEO, NY Neurology Medicine, PC5yrThis is an interesting study highlighting the fact that we are moving towards personalized medicine.
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Heidi Schwarz, Professor of Clinical Neurology, URMC5yrThis study highlights the coming of personalized medicine based on genomics (at least in part). 2 SNPs were found to be associated with migraine without aura and a specific Show More