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3yr
Long-Term Safety and Effectiveness of Erenumab in Patients with Migraine: A Systematic Review and Single-Arm Meta-analysis - Clinical Drug Investigation

Long-Term Safety and Effectiveness of Erenumab in Patients with Migraine: A Systematic Review and Single-Arm Meta-analysis - Clinical Drug Investigation

Source : https://link.springer.com/article/10.1007/s40261-022-01230-x

Background and Objective Several studies on use of erenumab for migraine treatment have been published over recent years. However, its long-term safety and effectiveness have not been consistently established in...


Conclusions: Erenumab has a favorable safety profile, with a low incidence of serious AEs, and sustained efficacy over ≥1 year of follow-up in the treatment of migraine."

  • 3yr
    Interesting read on qualitative and quantitative analysis of the long-term safety and effectiveness of erenumab for the treatment of migraine headaches.
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3yr
Opposite Regulation of Homer Signal at the NMJ Postsynaptic Micro Domain between Slow- and Fast-Twitch Muscles in an Experimentally Induced Autoimmune Myasthenia Gravis (EAMG) Mouse Model - PubMed

Opposite Regulation of Homer Signal at the NMJ Postsynaptic Micro Domain between Slow- and Fast-Twitch Muscles in an Experimentally Induced Autoimmune Myasthenia Gravis (EAMG) Mouse Model - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36499379/

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Relevance: In this study, we functionally characterize the novel and brain permeable GHB analog (E)-2-(5-hydroxy-2-phenyl-5,7,8,9-tetrahydro-6H-benzo[7]annulen-6-ylidene)acetic acid (Ph-HTBA).

  • 3yr
    Accelerated postsynaptic remodelling and disturbance of neuromuscular transmission are common features of autoimmune neurodegenerative diseases.
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3yr
The Polish Headache Society and the Headache Section of the Polish Neurological Society Consensus Statement: update on new pharmacological therapies for migraine in clinical practice and public medication reimbursement program for chronic migraine

The Polish Headache Society and the Headache Section of the Polish Neurological Society Consensus Statement: update on new pharmacological therapies for migraine in clinical practice and public medication reimbursement program for chronic migraine

Source : https://doi.org/10.5114/aoms/153955

The latest paper concerning the management of migraine in Poland was published in 2021 [ 1] and the previous one (in Polish) in 2019. The Polish recommendations were based on...



Relevance: The Polish recommendations were based on the guidelines of migraine treatment developed by the European Headache Federation (EHF, 2019) and the American Headache Society (AHS) published in 2021. The Polish guidelines took into consideration special Polish conditions and therapeutic options available in Poland, in regard to the...

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3yr

Can calcitonin gene-related peptide monoclonal antibody improve migraine and restless legs syndrome?

Source : https://www.jns-journal.com/article/S0022-510X(22)00324-0/fulltext

A significant association between migraine and restless legs syndrome (RLS) has been reported, and their coexistence is not uncommon. We report a patient with concomitant migraine and RLS who showed...


Conclusions: We report a case of improvement of both migraine and RLS after treatment with CGRP monoclonal antibody. Additional studies are needed to clarify how CGRP antagonism affects RLS symptoms in patients with migraine and RLS comorbidity.

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3yr
Two-year effectiveness of erenumab in resistant chronic migraine: a prospective real-world analysis - The Journal of Headache and Pain

Two-year effectiveness of erenumab in resistant chronic migraine: a prospective real-world analysis - The Journal of Headache and Pain

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-022-01507-8

Background Controlled and real-world evidence have demonstrated the efficacy of calcitonin gene related peptide (CGRP) monoclonal antibodies (MABs) in migraine. However, data on the over-one-year sustained effectiveness of CGRP MABs...


Conclusions: Long-term sustained effectiveness of erenumab was reported only by a minority of resistant CM patients. Although more research in resistant migraine is needed, Erenumab can provide long-term meaningful reduction in migraine load and migraine-related disability in some patients.