Deterioration of headache impact and health-related quality of life in migraine patients after cessation of preventive treatment with CGRP(−receptor) antibodies - The Journal of Headache and Pain
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-021-01368-7
Background Migraine preventive treatment with CGRP(−receptor) monoclonal antibodies (mAbs) has a positive effect on patients' health-related quality of life (HRQoL). The German treatment guidelines recommend discontinuing successful treatment with CGRP(−receptor)...
Our results show a significant decline in headache impact and generic HRQoL of migraine patients after treatment discontinuation of a CGRP(−R) mAb. The observed deterioration is above the established minimally clinically important differences for each of the questionnaires and can therefore be considered clinically meaningful. Monitoring HRQoL...
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Huma Sheikh, CEO, NY Neurology Medicine, PC4yrThis may be a good way to follow a patient, reinforces that cGRP is a good molecule to target.
Non-invasive vagus nerve stimulation for prevention of migraine: The multicenter, randomized, double-blind, sham-controlled PREMIUM II trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35001643/
1 WVU Headache Center, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA. 2 StudyMetrix Research, St. Peters, MO, USA. 3 Stanford University Medical Center, Palo Alto, CA, USA. 4...
Conclusions: These results suggest clinical utility of non-invasive vagus nerve stimulation for migraine prevention, particularly for patients who have migraine with aura, and reinforce the well-established safety and tolerability profile of this therapy.
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Huma Sheikh, CEO, NY Neurology Medicine, PC4yrThis is very important because we need more interventions that are not medications and possible tolerable in pregnancy, breast feeding or non oral. Good to see this.
Conclusion: RLS was more severe in patients with comorbid migraine. Vitamin D, calcium, and iron levels were significantly lower and inflammation markers were higher in all RLS patients. We think that further investigation of the underlying mechanisms of these two diseases and the results of population- based studies will enable clearer...
Nutrients to Improve Mitochondrial Function to Reduce Brain Energy Deficit and Oxidative Stress in Migraine
Source : https://www.mdpi.com/2072-6643/13/12/4433
The mechanisms of migraine pathogenesis are not completely clear, but 31P-nuclear magnetic resonance studies revealed brain energy deficit in migraineurs. As glycolysis is the main process of energy production in...
The nutrients that can be considered to supplement the diet to prevent and/or ameliorate migraine are riboflavin, thiamine, magnesium ions, niacin, carnitine, coenzyme Q10, melatonin, lipoic acid, pyridoxine, folate, and cobalamin. They can supplement a normal, healthy diet, which should be adjusted to individual needs determined mainly by the...
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Huma Sheikh, CEO, NY Neurology Medicine, PC4yrThis can be important in developing newer supplements to help.
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Dr Hamid4yrintake of caffeine and alcohol should be fine-tuned to the history of their use, as withdrawal of these agents in regular users may become a migraine trigger
Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0261570
Previous studies targeting inter-individual differences in pain processing in migraine mainly focused on the perception of pain. Our main aim was to disentangle pain anticipation and perception using a classical...
Both results suggest exaggerated preparatory responses to pain or more general to stressors, which may contribute to the allostatic load caused by stressors and migraine attacks on the brain.
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Huma Sheikh, CEO, NY Neurology Medicine, PC4yrInteresting!