What Is Known and What This Paper Adds: Familial HM (FHM) or sporadic HM has been associated with variations in 3 main genes, CACNA1A (FHM1), ATP1A2 (FHM2), and SCN1A (FHM3). Variants in PRRT2, the gene responsible for paroxysmal kinesigenic dyskinesia, have been reported in a few patients with HM. The results of this study establish PRRT2 as an...
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Huma Sheikh, CEO, NY Neurology Medicine, PC4yrThe genetic variations are very important to understand.
IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine - The Journal of Headache and Pain
Source : https://link.springer.com/article/10.1186/s10194-021-01374-9
Background Chronic migraine places a disabling burden on patients, which is extensively modeled by the nitroglycerin (NTG)-treated animal model. Although the NF-κB pathway is involved in an increase in CGRP...
Conclusions: This study confirmed that NTG (10 mg/kg, s.c., every 2 d for a total of 5 injections) was the optimal condition to provoke migraine, resulting in mechanical hyperalgesia and observable migraine-like behavior. Furthermore, IL-17A crossed the blood–brain barrier into the medulla oblongata, triggering TNC activation through...
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Huma Sheikh, CEO, NY Neurology Medicine, PC4yrQuite interesting in helping to understand how triggers may work.
Chronic migraine evolution after 3 months from erenumab suspension: real-world-evidence-life data - Neurological Sciences
Source : https://link.springer.com/article/10.1007/s10072-022-05870-x
Background Erenumab is a monoclonal antibody acting against calcitonin gene-related peptide receptor which has been found effective even for the treatment of chronic migraine (CM) complicated with medication overuse headache...
Conclusion: Patients affected by CM and MOH at the baseline displayed a significant worsening of their headaches after erenumab discontinuation.
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Huma Sheikh, CEO, NY Neurology Medicine, PC4yrSimilar study as another study which is reassuring.
The association between gastro-oesophageal reflux and migraine in the paediatric population: a multicentre case-control study - European Journal of Pediatrics
Source : https://link.springer.com/article/10.1007/s00431-021-04368-6
Infantile regurgitation is one of the most common discomforts in the first months of life. Infantile colic and, in older children, functional dyspepsia have been linked to migraine. To date,...
Conclusion: The presence of migraine among children aged 6–17 was associated with a history of infantile regurgitation. Additional longitudinal studies are required to confirm whether infantile regurgitation could be considered as a precursor of migraine.
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Huma Sheikh, CEO, NY Neurology Medicine, PC4yrWe know that the GI and nervous tract are all intertwined so this is not suprising.
Deterioration of headache impact and health-related quality of life in migraine patients after cessation of preventive treatment with CGRP(−receptor) antibodies - The Journal of Headache and Pain
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-021-01368-7
Background Migraine preventive treatment with CGRP(−receptor) monoclonal antibodies (mAbs) has a positive effect on patients' health-related quality of life (HRQoL). The German treatment guidelines recommend discontinuing successful treatment with CGRP(−receptor)...
Our results show a significant decline in headache impact and generic HRQoL of migraine patients after treatment discontinuation of a CGRP(−R) mAb. The observed deterioration is above the established minimally clinically important differences for each of the questionnaires and can therefore be considered clinically meaningful. Monitoring HRQoL...
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Huma Sheikh, CEO, NY Neurology Medicine, PC4yrThis may be a good way to follow a patient, reinforces that cGRP is a good molecule to target.