Effectiveness and safety of erenumab and galcanezumab in the prevention of chronic and episodic migraine: A retrospective cohort study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35212025/
WHAT IS KNOWN AND OBJECTIVE?: Erenumab and galcanezumab have shown great results for migraine prevention. However, strict inclusion criteria, absence of concomitant medication and selective outcome report of clinical trials...
Conclusion: Altogether, these results support previous real-life studies regarding effectiveness and safety and provide an interesting insight in how these preventive therapies are also effective in patients diagnosed with difficult to treat migraine who have previously failed, at least, three different drug classes stablished by current...
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrGood supporting data.
Behavioral Management of Episodic Migraine: Maintaining a Healthy Consistent Lifestyle - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35212864/
An individualized conceptualization of how lifestyle factors impact migraine activity has increased our understanding of the role of behavioral interventions for episodic migraine. Healthy diets of several types have been...
Conclusion/Relevance: Evidence is converging around the principle that highly unusual disruptions in daily routine are particularly associated with migraine attack onset and that a consistent healthy lifestyle is a key feature of effective behavioral migraine prevention strategies.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrThis is a good updated article to go to for advising patients.
Resting State Electrophysiological Cortical Activity: A Brain Signature Candidate for Patients with Migraine - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35182303/
A recent study examined differences in resting state functional connectivity among the pain-related regions and revealed that beta connectivity was attenuated in migraine and that altered connectivity in the anterior...
Conclusion/Relevance: Studies on resting state activity have yielded convincing findings regarding aberrant oscillatory power and functional connectivity in relation to migraine, thus contributing to identifying brain signatures for migraine. The role of such assessment in precision medicine should be further investigated.
Change in the second exteroceptive suppression period of the temporalis muscle during erenumab treatment - Naunyn-Schmiedeberg's Archives of Pharmacology
Source : https://link.springer.com/article/10.1007/s00210-022-02216-4
Comparative studies on the second exteroceptive suppression period (ES2) of the masseter or temporalis muscle in migraineurs and controls have provided conflicting results. As the interneurons responsible for ES2 are...
Conclusion: The change observed in the temporalis ES2 during erenumab treatment indicates that ES2 may play some kind of role as a neurophysiological marker and that this monoclonal antibody can modulate the brainstem circuits involved in migraine pathophysiology, at least indirectly. Further studies are required to confirm this intriguing...
CGRP-mediated trigeminovascular reactivity in migraine patients treated with erenumab
Source : https://jnnp.bmj.com/content/early/2022/01/26/jnnp-2021-327992
Migraine is a highly disabling disorder characterised by recurrent attacks of severe headache (https://ichd-3.org/). The trigeminovascular system and release of calcitonin gene-related peptide (CGRP), a neuromodulator and potent vasodilator, have...
Relevance: We evaluated whether erenumab inhibits the forehead capsaicin-induced DBF response and whether the degree of capsaicin-induced DBF response before treatment is different in patients with an adequate versus suboptimal clinical response to erenumab.
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Dr Hamid3yrMigraine is a highly disabling disorder characterised by recurrent attacks
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrThis is interesting to see the reactions.