Comparing the relative and absolute effect of erenumab: is a 50% response enough? Results from the ESTEEMen study - The Journal of Headache and Pain
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-022-01408-w
Background Monoclonal antibodies acting on the calcitonin gene-related peptide (CGRP) or its receptor have changed migraine preventive treatment. Those treatments have led to reconsidering the outcomes of migraine prevention. Available...
Relevance: In the present study, we aimed at comparing the relative and absolute efficacy of erenumab.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrUnfortunately, we have always considered 50% to be "success"
Cervical musculoskeletal impairments in the 4 phases of the migraine cycle in episodic migraine patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35332826/
In all phases of the migraine cycle, independent of the presence of concomitant neck pain, episodic migraine patients showed reduced flexion rotation test and craniocervical flexion test and an increased...
Conclusion: In all phases of the migraine cycle, independent of the presence of concomitant neck pain, episodic migraine patients showed reduced flexion rotation test and craniocervical flexion test and an increased number of myofascial trigger points and passive accessory vertebral segments. These impairments are correlated with enhanced...
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrMuscle and Neck pain are so common, this is a good review
A 28-year-old female presents to your office with a headache that is throbbing and affecting the left-side of her head. She also reports nausea and had one episode of vomiting. Her symptoms began approximately 6 hours ago, where she began to see a bright light that progressively expanded. Resting in a quiet dark room diminished her symptoms. She...
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrIt depends if this is the first headache or she has a history of them. This seems like a typical migraine with aura but if it is the first Show More
42 yo woman who is now 4 months pregnant with hx of migraine, was previously well-controlled on Botox and nerve blocks, albeit still with consistent headaches. We are continuing to do nerve blocks, but she would also like to resume Botox. She is having almost daily headaches now since being off of Botox for almost 5 months. What would you do?
Could the New Anti-CGRP Monoclonal Antibodies Be Effective in Migraine Aura? Case Reports and Literature Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35268319/
1 Regional Referral Headache Center, Neurology Unit, University Hospital Tor Vergata, 00133 Rome, Italy. 2 Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy. 3 IRCCS Santa...
Conclusion: In this paper, we report two cases of patients suffering from migraine with and without aura, who reported a complete disappearance of aura or reduced aura duration and intensity while taking Galcanezumab or Erenumab, respectively. Then, we present a brief overview of the literature about the controversial relationship between CSD...
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Dr Hamid3yrBecause of their large size, mAbs cannot easily cross the blood-brain barrier in high quantities, rendering the peripheral trigeminovascular system to likely be a major site of their action.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrTheoretically it should be.