Risk factors of white matter hyperintensities in migraine patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35488255/
Older age, longer disease duration, frequent attacks, and high serum homocysteine level are main the risk factors for WMHs in this cohort. The severity or duration of migraine attacks did...
Conclusion: Older age, longer disease duration, frequent attacks, and high serum homocysteine level are main the risk factors for WMHs in this cohort. The severity or duration of migraine attacks did not increase the frequency of WMHs. The number of WMHs was significantly higher in chronic compared to episodic migraineurs.
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Migraine Connect3yrKey Points • Source: BMC Neurology • Conclusion: “Older age, longer disease duration, frequent attacks, and high serum homocysteine level are main the risk factors for WMHs in this cohort. The severity or duration Show More
Central effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35484504/
doi: 10.1186/s10194-022-01421-z. 1 Applied Neurophysiology and Pain Unit, Bari Aldo Moro UniversityPoliclinico General Hospital, Piazza Giulio Cesare 11, 70124, Bari, Italy. [email protected]. 2 Dipartimento Interateneo di Fisica 'M. Merlin', Università...
Conclusions: The present pilot study indicates that Galcanezumab could act on cortical targets located beyond the pain network, restoring the abnormal occipital reactivity. This effect could indicate the possible disease modifying properties of CGRP related monoclonal antibodies.
Erenumab in chronic migraine: experience from a UK tertiary centre and comparison with other real-world evidence - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35445471/
doi: 10.1111/ene.15364. Online ahead of print. 1 ¹NIHR-Wellcome Trust King's Clinical Research Facility, King's College Hospital, London. 2 Headache Group, Wolfson CARD, Institute of Psychiatry, Psychology and Neuroscience, King's College...
Conclusion: Our real-world data with erenumab demonstrate it is effective and well-tolerated in managing patients with chronic migraine in a tertiary care setting.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrMore real time data is important.
Beneficial Effects of Capsaicin in Disorders of the Central Nervous System - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35458680/
Capsaicin is a natural compound found in chili peppers and is used in the diet of many countries. The important mechanism of action of capsaicin is its influence on TRPV1...
Relevance: The purpose of this review is to discuss the mechanisms of the beneficial effects of capsaicin in disorders of the central nervous system.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrThese can be important way to treat trigeminal neuralgia.
Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35457225/
Migraine is a disabling neurovascular disorder characterized by severe pain with still limited efficient treatments. Endocannabinoids, the endogenous painkillers, emerged, alternative to plant cannabis, as promising analgesics against migraine pain....
Conclusion/Relevance: The specific distribution and homeostasis of endoCBs in the main regions of the nociceptive system and their generation 'on demand', along with recent availability of MAGL and FAAH inhibitors suggest new perspectives for endoCBs-mediated analgesia in migraine pain.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrThere should be more research with this.
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Migraine Connect3yrKey Points • Source: International Journal of Molecular Sciences • Conclusion: “The specific distribution and homeostasis of endoCBs [endocannabinoids] in the main regions of the nociceptive system and their generation ‘on demand’, along with Show More