Calcitonin gene-related peptide-targeting drugs and Raynaud's phenomenon: a real-world potential safety signal from the WHO pharmacovigilance database - The Journal of Headache and Pain
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-022-01424-w
Background Migraine is responsible for significant disability and societal burden. Recently, drugs targeting the calcitonin gene-related peptide (CGRP) pathway raised new hopes. CGRP, a potent vasodilator, plays a key role...
Conclusions: There is a significant disproportionality signal of Raynaud’s phenomenon with CGRP-targeting. This signal stands out when CGRP-targeting drugs are compared to other drugs used in patients with migraine. This study is limited by missing data in pharmacovigilance reports. CGRP-targeting drugs may be subject to Weber effect and...
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrVery interesting.
Annual indirect cost savings in patients with episodic or chronic migraine: post-hoc analyses from multiple galcanezumab clinical trials - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35510376/
doi: 10.1080/13696998.2022.2071528. Online ahead of print. 1 Neurosciences Clinic, Banner University Medical Center, 755 E McDowell Rd, Phoenix, AZ 85006, USA. 2 Eli Lilly and Company, Lilly Corporate Center, 893...
Conclusion: GMB treatment resulted in annual indirect cost savings in patients with EM, CM, and with previous failure of 2-4 migraine preventive medication categories, with similar observations in the sensitivity analyses.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrThis is an important aspect of treating migraine.
Lithium use associated with symptom severity in comorbid bipolar disorder I and migraine - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35510536/
Herein, we replicate the relatively worse outcome in BD with comorbid migraine. We find evidence to suggest that lithium use is associated with more severe symptoms of mania among those...
Conclusions: Herein, we replicate the relatively worse outcome in BD with comorbid migraine. We find evidence to suggest that lithium use is associated with more severe symptoms of mania among those with BD and a history of migraine and conclude that lithium is contraindicated in BD comorbid with migraine.
Development and validation of a web-based headache diagnosis questionnaire - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35488015/
2022 Apr 29;12(1):7032. doi: 10.1038/s41598-022-11008-y. 1 Department of Neurology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. 2 Hankook Research, Seoul, Korea. 3...
Conclusion: The best agreement was found in migraine (sensitivity: 92.6%; specificity: 94.8%; kappa coefficient: 0.875), followed by TTH (sensitivity: 78.4%; specificity: 98.4%; kappa coefficient: 0.809). PM showed the least agreement (sensitivity: 85.0%; specificity: 92.9%; kappa coefficient: 0.757). In conclusion, our questionnaire is valid in...
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrThis can make it easier for patients to seek out treatment.
The use of erenumab for migraine prophylaxis during pregnancy: A case report and narrative review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35467013/
The use of erenumab during pregnancy in our patient resulted in no known harm to the child. This case is unique in that the mother continued to receive erenumab throughout...
Conclusions: The use of erenumab during pregnancy in our patient resulted in no known harm to the child. This case is unique in that the mother continued to receive erenumab throughout the pregnancy. Safety data is lacking regarding the use of these agents during pregnancy, despite their frequent use in women of childbearing potential.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrNeed more studies to evaluate.