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A 38-year-old male patient reports having an increasing number of headaches per month. He has suffered from migraines for over a decade which have been increasing slowly. He has been diagnosed with chronic migraine and suffers from moderate-to-severe migraine with nausea that lasts 12 hours about 8 times a month. In the last 2 years, he has also endured more frequent headaches occurring at least five days a week which are moderate in nature with throbbing and photophobia. Currently he takes a triptan (Imitrex, Zomig, etc.) to manage migraines but also uses over-the-counter simple analgesics or combination pain relievers to help manage his headaches. The patient also has associated neck pain, with tenderness in her neck and shoulder muscles.



Currently, this patient has a BMI of 30, is a regular smoker, drinks coffee daily, and suffers from Irritable Bowel Syndrome (IBS).



What treatment(s) would you recommend for this patient? What factors would you consider when deciding how to treat this patient? What preventive medicines are possible in his situation?



 


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Behavioral and psychological factors in individuals with migraine without psychiatric comorbidities - The Journal of Headache and Pain

Behavioral and psychological factors in individuals with migraine without psychiatric comorbidities - The Journal of Headache and Pain

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-022-01485-x

Background It is well known that the course of migraine is influenced by comorbidities and that individual psychological characteristics may impact on the disease. Proper identification of psychological factors that...


Conclusions: Even in individuals without psychiatric comorbidities, specific behavioral and psychological factors are associated with migraine, especially in its chronic form. Proper identification of those factors is important to improve management of migraine through non-pharmacological strategies.

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Nummular headache responsive to anti-calcitonin gene-related peptide monoclonal antibodies in a patient with migraine - PubMed

Nummular headache responsive to anti-calcitonin gene-related peptide monoclonal antibodies in a patient with migraine - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36018002/

doi: 10.1111/head.14372. Online ahead of print. 1 Department of Neurology, Hospital Reina Sofía, Tudela, Navarra, Spain. 2 Aragon Institute for Health Research (IIS Aragon), Zaragoza, Spain. 3 Neurology Department, Donostia...


Conclusions: Monoclonal antibodies against calcitonin gene-related peptide (CGRP), in particular galcanezumab, might be an effective therapy in some patients with NH. CGRP may have a role in the etiopathogenesis of this headache, which warrants further investigation.

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Outpatient Approach to Resistant and Refractory Migraine in Children and Adolescents: a Narrative Review - PubMed

Outpatient Approach to Resistant and Refractory Migraine in Children and Adolescents: a Narrative Review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36018499/

In this review, we summarize the level of evidence for a variety of acute and preventive treatment options to consider in children and adolescents with resistant or refractory migraine. We...


Relevance: In this review, we summarize the level of evidence for a variety of acute and preventive treatment options to consider in children and adolescents with resistant or refractory migraine.

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The Role of High-Conductance Calcium Activated Potassium Channel in Headache and Migraine Pathophysiology - PubMed

The Role of High-Conductance Calcium Activated Potassium Channel in Headache and Migraine Pathophysiology - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36028922/

Migraine is a common, neurovascular headache disorder with a complex molecular interplay. The involvement of ion channels in the pathogenesis of migraine gathered considerable attention with the findings that different...


Relevance: Recent clinical research revealed that infusion of BKCa channel opener MaxiPost caused vasodilation, headache and migraine attack. Thus, BKCa channel is involved in pathophysiological mechanisms underlying headache and migraine, and targeting BKCa channel presents a new potential strategy for migraine treatment.