Circadian Pain Patterns in Human Pain Conditions - A Systematic Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35869813/
doi: 10.1111/papr.13149. Online ahead of print. 1 Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL, USA. 2 Department of Anesthesiology, University of Illinois, Chicago, IL, USA. 3 Department...
Conclusion: The results of this review suggest that an understanding of diurnal variation may help improve therapeutic strategies in pain management, for instance through analgesic titration.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrThis is present in many headache syndromes.
CGRP-Targeted Therapy for Episodic and Chronic Cluster Headache - Current Pain and Headache Reports
Source : https://link.springer.com/article/10.1007/s11916-022-01070-6
Purpose of Review Chronic cluster headache (CH) substantially affects patients' quality of life, and treatment remains challenging. The current article reviewed controlled studies for new treatment options targeting calcitonin gene-related...
Summary: There are no randomized controlled trials for CGRP-targeted therapies that showed efficacy for chronic CH prevention. The different responses to galcanezumab between episodic and chronic CH may be due to the study design, i.e., the allowance of concomitant preventive therapies in the chronic CH study but not in the episodic CH study....
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrNeed more and more to allow insurance coverage.
Long-term reductions in disease impact in patients with chronic migraine following preventive treatment with eptinezumab - BMC Neurology
Source : https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02774-3
Background Eptinezumab is an anti-calcitonin gene-related peptide humanized monoclonal antibody approved for the preventive treatment of migraine in adults. The PREVAIL study demonstrated a favorable safety profile with sustained reductions...
Conclusions: Long-term treatment with eptinezumab in patients with CM suggested sustained reductions in MIDAS-quantified disability, consistent with the sustained reductions in headache frequency and pain severity.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrHappy to see real life follow up studies.
Migraine among Saudi Arabians | IJGM
Mammalian mitochondrion is found to own a specific deoxyribonucleic acid (DNA) in its matrix. Mitochondrion DNA (mtDNA) is responsible for the transcription of essential proteins for the mitochondrial function. As...
Conclusion: This is the first study to demonstrate the association of mtDNA variations with migraine in the Saudi population. The current findings will help to highlight the significance of mtDNA mutations to migraine pathophysiology and will serve as a reference data for larger national and international studies.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrVery interesting!
Migraine With Comorbid Depression: Pathogenesis, Clinical Implications, and Treatment
Migraine is a neurological disorder that strongly relates to psychiatric conditions like depression. Lately, the increased prevalence of depression in migraineurs has come to attention. This article compiled various literature...
Conclusion/Relevance: Migraine with comorbid depression (MID) affects various aspects of life and its clinical impact on migraine disability, quality of life (QOL), progression, and medication overuse was investigated. We further inspected several types of research in order to provide options on various treatment modalities. Pharmacotherapy such...
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrSo important to focus on the psychiatric and psychological co morbidities.
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Migraine Connect3yrKey Points • Source: Cureus • Relevance: “Migraine is a neurological disorder that strongly relates to psychiatric conditions like depression. Lately, the increased prevalence of depression in migraineurs has come to attention. Show More