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3yr
Role of endothelin in the pathophysiology of migraine: A new view on an old player

Role of endothelin in the pathophysiology of migraine: A new view on an old player

Source : https://www.sciencedirect.com/science/article/abs/pii/S0143417922000610?via=ihub

There is cumulating evidence that endothelin-1 (ET-1) may play a role in migraine, however controversial findings still impede a conclusion to be drawn. Herein we tested the hypothesis that endothelin...


Conclusion: Selective blockade of ETB receptors in the TG fully prevented the development of periorbital mechanical allodynia and photic sensitivity induced by CGRP, but ETA receptor blockade caused only a slight reduction of periorbital mechanical allodynia without affecting photic sensitivity. ETB receptor-operated mechanisms in the TG may...

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3yr
Bidirectional Association Between Fibromyalgia and Migraine Among Probands and Unaffected Non-Twin Siblings: A Nationwide Population-Based Study - PubMed

Bidirectional Association Between Fibromyalgia and Migraine Among Probands and Unaffected Non-Twin Siblings: A Nationwide Population-Based Study - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36054795/

doi: 10.1111/papr.13160. Online ahead of print. 1 Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. 2 Department of Psychiatry, Taipei Veterans General Hospital, Taipei,...


Conclusion: The bidirectional association between fibromyalgia and migraine among probands and unaffected siblings suggests a familial coaggregation of these two conditions. Additional studies are required to investigate the genetic and environmental etiologies for this coaggregation.

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3yr
Level of therapeutic innovation from the registration studies of the new drugs for the prophylaxis of migraine - PubMed

Level of therapeutic innovation from the registration studies of the new drugs for the prophylaxis of migraine - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36054749/

The new monoclonal antibodies of the class of CGRP targeting therapies have been authorized with efficacy data only against placebo. They do not offer additional clinical benefits compared to available...


Discussion: The new monoclonal antibodies of the class of CGRP targeting therapies have been authorized with efficacy data only against placebo. They do not offer additional clinical benefits compared to available therapies for the prevention of migraine attacks, with the exception of a lower frequency of administration and a more rapid effect....

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3yr
Salivary CGRP and Erenumab Treatment Response: Towards Precision Medicine in Migraine - PubMed

Salivary CGRP and Erenumab Treatment Response: Towards Precision Medicine in Migraine - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36054144/

Patients with migraine not only have higher CGRP levels compared with HCs, but also the presence of depressive symptoms seems to increase salivary CGRP levels and we have evidence, for...


Interpretation: Patients with migraine not only have higher CGRP levels compared with HCs, but also the presence of depressive symptoms seems to increase salivary CGRP levels and we have evidence, for the first time, that baseline salivary CGRP concentration is associated with treatment response to erenumab.

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3yr
Investigation on how dynamic effective connectivity patterns encode the fluctuating pain intensity in chronic migraine

Investigation on how dynamic effective connectivity patterns encode the fluctuating pain intensity in chronic migraine

Source : https://www.sciencedirect.com/science/article/pii/S2452073X22000174?via=ihub

Chronic migraine is characterised by persistent headaches for >15 days per month; the intensity of the pain is fluctuating over time. Here, we explored the dynamic interplay of connectivity patterns...


Conclusion/Relevance: The results reflect the multi-facetted clinical picture of the disease. Across all sessions, each patient with chronic migraine exhibited a distinct pattern of pain intensity-related cortical connectivity. The diversity of the individual findings are accompanied by inconsistent relations between the connectivity...