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3yr
Childhood cancer confers increased risk of migraine - A Danish nationwide register study

Childhood cancer confers increased risk of migraine - A Danish nationwide register study

Source : https://www.sciencedirect.com/science/article/pii/S1877782122001837?via=ihub

Danish nationwide registers give unbiased estimates of migraine prevalence among individuals diagnosed with childhood cancer. * Childhood cancer confers increased risk of initiating prescription migraine therapy and being hospitalized for...


Conclusions: Individuals diagnosed with childhood cancer have a higher risk of migraine of varying presentations, in addition to migraine resulting in hospitalization as previously reported. This potentially preventable problem warrants clinical attention.

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3yr
Cranial autonomic symptoms and response to monoclonal antibodies targeting the Calcitonin gene-related peptide pathway: A real-world study

Cranial autonomic symptoms and response to monoclonal antibodies targeting the Calcitonin gene-related peptide pathway: A real-world study

Source : https://www.frontiersin.org/articles/10.3389/fneur.2022.973226/full

ObjectiveCranial autonomic symptoms (CAS), including conjunctival injection, tearing, nasal congestion or rhinorrhea, eyelid edema, miosis or ptosis, and forehead or facial sweating ipsilateral to headache, are often reported by patients...


Conclusions: In our cohort, the presence of CAS was associated with a greater response to monoclonal antibodies targeting the CGRP pathway. CAS could be a clinical marker of trigeminovascular activation and thus be related to a better response to CGRP treatments.

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3yr
Examining the correlation between salivary cytokine concentrations and CRP in people experiencing social-cognitive stress

Examining the correlation between salivary cytokine concentrations and CRP in people experiencing social-cognitive stress

Source : https://www.tandfonline.com/doi/abs/10.1080/01616412.2022.2126681?journalCode=yner20

ABSTRACT The study aims to determine the relationship of migraine and chronic tension-type headache (TTHs) with alterations in the salivary markers of inflammation . - The prospective study involved 75...


Conclusions: The relationship of CRP, IL1-β, and IL-6 concentrations with migraine and chronic TTH has been established. No statistically significant differences were found in the dynamics between migraine and chronic TTH groups. There was a direct correlation of migraine and chronic TTH with anxiety and depression.

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3yr
Alterations in metabolic flux in migraine and the translational relevance - The Journal of Headache and Pain

Alterations in metabolic flux in migraine and the translational relevance - The Journal of Headache and Pain

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-022-01494-w

Background Migraine is a highly prevalent disorder with significant economical and personal burden. Despite the development of effective therapeutics, the causes which precipitate migraine attacks remain elusive. Clinical studies have...


Conclusion: Migraine susceptibility may be underpinned by impaired metabolism resulting in depleted energy stores and altered neuronal function. This review discusses both clinical and in vivo studies which provide evidence of altered metabolic flux which contribute toward pathophysiology. It also reviews the translational relevance of animal...

  • 3yr
    I completely agree that there are likely metabolic changes that are occuring.
  • 3yr
    Key Points • Source: The Journal of Headache and Pain • Conclusion: “Migraine susceptibility may be underpinned by impaired metabolism resulting in depleted energy stores and altered neuronal function. This review discusses both clinical Show More
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3yr
Gestational exposure to erenumab-The outcome of three pregnancies - PubMed

Gestational exposure to erenumab-The outcome of three pregnancies - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36151771/

Erenumab is a monoclonal antibody (mAb) approved for the preventive treatment of migraine. While preclinical studies on calcitonin gene-related peptide mAbs did not identify any reproductive toxicity, pregnant and breastfeeding...


Conclusion/Relevance: No plausible explanation relates the mechanism of action of erenumab and the serious complication that occurred in one patient. Continuous follow-up and reporting of all exposures are encouraged to gather safety data on pregnant and nursing women and on the development of the newborns. So far, immediately stopping the drug...