Refractory Headaches
Source : https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0042-1757925
Semin Neurol 2022; 42(04): 512-522DOI: 10.1055/s-0042-1757925 1 Headache Specialist at Hartford HealthCare, Hartford, Connecticut 3 Department of Neurology, Brigham and Women's Faulkner Hospital J Graham Headache Center, Boston,...
Relevance: Medication overuse headache (MOH), new daily persistent headache (NDPH), and persistent refractory headache attributed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection represent a significant burden in terms of disability and quality of life, and a challenge in terms of definition, pathophysiology, and...
OnabotulinumtoxinA in elderly patients with chronic migraine: insights from a real-life European multicenter study - Journal of Neurology
Source : https://link.springer.com/article/10.1007/s00415-022-11457-5
Introduction Although migraine prevalence decreases with aging, some older patients still suffer from chronic migraine (CM). This study aimed to investigate the outcome of OnabotulinumtoxinA (OBT-A) as preventative therapy in...
Conclusions: In a population of elderly CM patients with a long history of migraine OBT-A provided a significant benefit, over the first three treatment cycles, as good as in non-old patients.
The contribution of the left precuneus to emotion memory in migraine without aura patients
Source : https://www.frontiersin.org/articles/10.3389/fnins.2022.905942/full
BackgroundThe impact of migraine without aura (MWoA) on cognitive function remains controversial, especially given the sparse literature on emotional memory.MethodsTwenty seven MWoA patients and 25 healthy controls (HCs) were enrolled...
Conclusions: Our study demonstrated the tendency for the influence of migraine on emotional memory and revealed the left precuneus as a critical contributor to recollection performance, providing novel insights for understanding emotional memory and its neural mechanisms in MWoA patients.
Serum Calcitonin Gene-Related Peptide Is Elevated in... : Journal of Neuro-Ophthalmology
pathy [RPON]). As migraine is associated with elevated serum calcitonin gene-related peptide (CGRP) levels, we studied serum CGRP levels among patients with OM/RPON to determine whether they are elevated during...
Conclusions: Elevated serum CGRP levels during the ictal phase of OM/RPON favor migraine as the underlying cause of episodic headache with ophthalmoplegia.
Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36297301/
2022 Sep 27;15(10):1189. doi: 10.3390/ph15101189. 1 Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Glostrup, 2600 Copenhagen, Denmark. 2 Department of Neurorehabilitation/Traumatic Brain Injury, Rigshospitalet, 2100 Copenhagen, Denmark. Free PMC...
Conclusions: Human studies into the pathophysiological underpinnings of CGRP and PACAP in migraine are manifold and here we review the works investigating these neuropeptides in patients suffering from migraine in order to elucidate the background for developing new treatment options for this vastly disabling disorder.