Bioinformatics and network pharmacology analysis of drug targets and mechanisms related to the comorbidity of epilepsy and migraine
Source : https://www.sciencedirect.com/science/article/abs/pii/S0920121122002170?via=ihub
The present study aimed to explore the mechanisms underlying the comorbidity of epilepsy and migraine, identify potential common targets for drug intervention, and provide insight into new avenues for disease...
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Conclusions: Our systematic and comprehensive analyses of disease–gene–target–drug interaction networks identified several biological processes and molecular functions common to migraine and epilepsy, most of which were related to neuroactive ligand-receptor interactions. These data provide a new theoretical basis and reference for the clinical treatment of comorbid epilepsy and migraine and may aid in the development of novel pharmacological strategies.
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Huma Sheikh, CEO, NY Neurology Medicine, PCJanuary 09, 2023a good review.
Primary headache disorders in Latin America and the Caribbean: A meta-analysis of population-based studies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36606574/
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Conclusions: Primary headache disorders in Latin America and the Caribbean: A meta-analysis of population-based studies
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Huma Sheikh, CEO, NY Neurology Medicine, PCJanuary 09, 2023This is great information.
Lichenoid drug eruption induced by erenumab - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36606202/
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Conclusions: LDE, or drug-induced lichen planus, is a rare, T-cell mediated, cutaneous adverse event of a myriad of drugs. The most common culprits include antihypertensives, diuretics, antimalarials, non-steroidal antiinflammatory drugs, and antitubercular drugs.
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Huma Sheikh, CEO, NY Neurology Medicine, PCJanuary 09, 2023Interesting side effect.
Effectiveness and Safety of Chronic Migraine Preventive Treatments: A Systematic Literature Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36417165/
doi: 10.1007/s40122-022-00452-3. Online ahead of print. 1 The Los Angeles and San Diego Headache Centers, San Diego, CA, USA. 2 Bridge Medical Consulting Ltd, Richmond, London, UK. 3 AbbVie, 2525...
Conclusions: "Conclusion: While substantial real-world evidence supports the long-term effectiveness and safety of onabotulinumtoxinA, real-world data on other preventive treatments of CM are currently limited to short term effectiveness due to their more recent approvals."
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Dr HamidDecember 21, 2022Interesting article - Substantial data demonstrated that onabotulinumtoxinA reduces the number/frequency of headaches, concomitant acute medication use, and impact of headaches on well-being and daily activity.
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Huma Sheikh, CEO, NY Neurology Medicine, PCDecember 03, 2022This is important to have insurance be on board as well.
Long-Term Safety and Effectiveness of Erenumab in Patients with Migraine: A Systematic Review and Single-Arm Meta-analysis - Clinical Drug Investigation
Source : https://link.springer.com/article/10.1007/s40261-022-01230-x
Background and Objective Several studies on use of erenumab for migraine treatment have been published over recent years. However, its long-term safety and effectiveness have not been consistently established in...
Conclusions: Erenumab has a favorable safety profile, with a low incidence of serious AEs, and sustained efficacy over ≥1 year of follow-up in the treatment of migraine."
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Dr HamidDecember 21, 2022Interesting read on qualitative and quantitative analysis of the long-term safety and effectiveness of erenumab for the treatment of migraine headaches.