Change of CGRP Plasma Concentrations in Migraine after Discontinuation of CGRP-(Receptor) Monoclonal Antibodies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36678920/
Discontinuation of treatment with monoclonal antibodies (mAb) targeting the Calcitonin Gene-Related Peptide (CGRP) pathway leads to an increase in migraine frequency. We aimed to assess changes in free and total...
Conclusions: Cessation of treatment with CGRP(-R) mAbs did not have an impact on the free-circulating CGRP concentrations. Total CGRP decreased significantly after three months of treatment discontinuation.
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Huma Sheikh, CEO, NY Neurology Medicine, PCFebruary 04, 2023Interesting, how is psoriasis diagnosed?
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Dr HamidJanuary 30, 2023psoriasis patients are predisposed to a significantly higher risk of migraine, particularly migraine with aura
Evaluation of the relationship between migraine and psoriasis: a case-control study
Source : https://www.sciencedirect.com/science/article/pii/S0365059622003178?via=ihub
Available online 19 January 2023 Author links open overlay panel Mohamad Sarkhani Doctor of Medicine Person Envelope a Majid Rostami Mogaddam b Ghasem Fattahzadeh-Ardalani c Nasrin Fouladi d Show more...
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Conclusions: In comparison with the non-psoriatic control group, psoriasis patients are predisposed to a significantly higher risk of migraine, particularly migraine with aura, psoriasis patients with more severe disease and those with PsA have a markedly higher risk of having migraine, and the migraine headache index is significantly higher in psoriasis patients.
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Dr HamidJanuary 30, 2023psoriasis patients are predisposed to a significantly higher risk of migraine, particularly migraine with aura,
Characterization of trigeminal C-fiber reactivity through capsaicin-induced release of calcitonin gene-related peptide - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36705344/
Our results suggest that the trigeminovascular system reacts differently from extracephalic areas, which may explain the trigeminal susceptibility to CGRP-mediated pain attacks. By demonstrating a different reactivity of the V1...
Conclusions: Our results suggest that the trigeminovascular system reacts differently from extracephalic areas, which may explain the trigeminal susceptibility to CGRP-mediated pain attacks. By demonstrating a different reactivity of the V1 dermatome in patients with migraine, our finding suggests that the first trigeminal branch is functionally different from the second and third branches; however, only in patients with migraine.
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Altered functional connectivity of the right caudate nucleus in chronic migraine: a resting-state fMRI study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36460958/
Our results revealed abnormal right CN-based FC values in CM patients, suggesting dysfunction of brain networks associated with pain perception and multi-regulation (emotion, cognition, and sensory). Aberrant FC of the...
Conclusions: "Our results revealed abnormal right CN-based FC values in CM patients, suggesting dysfunction of brain networks associated with pain perception and multi-regulation (emotion, cognition, and sensory). Aberrant FC of the CN can provide potential neuroimaging markers for the diagnosis and treatment of CM."
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Huma Sheikh, CEO, NY Neurology Medicine, PCJanuary 09, 2023Helpful to know how much the entire brain is involved in migraine.
Potential Contribution of Hypertension to Evolution of Chronic Migraine and Related Mechanisms
Source : https://www.quintpub.com/journals/ofph/abstract.php?iss2_id=1474&article_id=22762#.Y4xJk3bMJwU
Matteo Cotta Ramusino, MD, PhD/Giulia Perini, MD/Marco Capelli, MD/Gloria Vaghi, MD/Roberto Fogari, MD/Daniele Bosone, MD/Alfredo Costa, MD: Aims: To investigate the potential contributions of diastolic and systolic blood pressure (BP)...
Conclusions: These findings suggest that hypertension may contribute to the chronic evolution of headache with mechanisms shared with migraine; ie, vascular tone alteration and autonomic dysregulation.
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Huma Sheikh, CEO, NY Neurology Medicine, PCJanuary 09, 2023This makes sense.