New migraine prophylactic drugs: Current evidence and practical suggestions for non-responders to prior therapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36759320/
New prophylactic drugs that target the CGRP pathway are promising treatment options for patients with difficult-to-treat migraine. Individualized approaches using a combination of new substances with oral prophylactic drugs or botulinum toxin A, switching between new drugs, and adjusting treatment d ...
Conclusions: New prophylactic drugs that target the CGRP pathway are promising treatment options for patients with difficult-to-treat migraine. Individualized approaches using a combination of new substances with oral prophylactic drugs or botulinum toxin A, switching between new drugs, and adjusting treatment duration could enhance excellence in practice.
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Huma Sheikh, CEO, NY Neurology Medicine, PCFebruary 16, 2023This is really needed.
Effectiveness and safety of CGRP monoclonal antibodies in migraine related to mitochondrial diseases in patients with NARP and PEO syndromes
Source : https://www.sciencedirect.com/science/article/abs/pii/S0303846723000276?via=ihub
Migraine or migraine-like headaches are a prominent feature of mitochondrial disorders (MD) with a prevalence ranging from 29% to 58% independently from diseases' genotypes or phenotypes, expression of the central...
Conclusions: Herein, we report the cases of a patient with neuropathy, ataxia, and retinitis pigmentosa syndrome (NARP) and a patient with progressive external ophthalmoplegia (PEO), both with a clinical phenotype including chronic migraine, for which treatment with Galcanezumab was started.
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Huma Sheikh, CEO, NY Neurology Medicine, PCFebruary 16, 2023May be a good expansion of use.
Psychological Resilience & Stress Coping Styles in Migraines | NDT
Stress is the most commonly known factor that triggers migraine pain. When the behavioral or physiological stressors are frequent/severe, allostatic loading happens. So, both functional and structural changes occur in the brain network and this condition leads the person to give abnormal reactions to environmental factors and the disease to become chronic.
Conclusions: Self-confident approach, social support-seeking approach, and level of psychological well-being predict psychological resilience in migraine patients. Interventions aiming to increase the level of psychological resilience, which is negatively correlated with depression, are expected to increase the quality of life of patients with migraine.
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Huma Sheikh, CEO, NY Neurology Medicine, PCFebruary 04, 2023Stress is a huge factor in migraine.
Eptinezumab improved patient-reported outcomes in patients with migraine and medication-overuse headache: Subgroup analysis of the randomized PROMISE-2 trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36633219/
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Conclusions: This subgroup analysis in patients with CM/MOH at baseline suggests that eptinezumab treatment is associated with early, sustained, and clinically meaningful improvements in patient-reported outcomes.
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Huma Sheikh, CEO, NY Neurology Medicine, PCFebruary 04, 2023THis is great to see.
Nutrition and Calcitonin Gene Related Peptide (CGRP) in Migraine - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36678160/
Targeting calcitonin gene-related peptide (CGRP) and its receptor by antibodies and antagonists was a breakthrough in migraine prevention and treatment. However, not all migraine patients respond to CGRP-based therapy and...
Conclusions: This narrative review presents information on molecular aspects of the interaction between dietary nutrients and CGRP and their reported and prospective use to improve anti-CGRP therapy in migraine.
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Huma Sheikh, CEO, NY Neurology Medicine, PCFebruary 04, 2023This is the wave of migraine treatment.
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Dr HamidJanuary 30, 2023Targeting calcitonin gene-related peptide (CGRP) and its receptor by antibodies and antagonists was a breakthrough in migraine prevention and treatment.