Sex Hormones and Calcitonin Gene-Related Peptide in Women With Migraine: A Cross-sectional, Matched Cohort Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36813730/
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Conclusions: Different sex hormone profiles may influence CGRP concentrations in people, with current or past capacity to menstruate, with migraine. Measurement of CGRP in tear fluid was feasible and warrants further investigation.
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Huma Sheikh, CEO, NY Neurology Medicine, PCMarch 03, 2023This is a good article.
Fremanezumab for Migraine Prevention in Japanese Elderly Aged Over 70 Years Old
Background Elderly migraine is a public health problem with prolonged life expectancy, and effective prophylactic treatment is needed. There were no reports on fremanezumab for the elderly. We described the real-world data of fremanezumab, calcitonin gene-related peptide-related monoclonal antibody (CGRP-mAB), for migraine in elderly over 70 years old.
Conclusions: We described the six elderly migraine patients aged over 70 years old treated with fremanezumab. Two (33.3%) of the six patients experienced therapeutic effectiveness. This is the first report of fremanezumab for elderly migraine patients aged over 70 years old. Further evidence accumulation is needed about CGRP-mABs for the elderly.
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Huma Sheikh, CEO, NY Neurology Medicine, PCMarch 03, 2023great review article
A study of differential microRNA expression profile in migraine: the microMIG exploratory study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36797674/
A 3-miRNA (miR-342-3p, miR-532-3p and miR-758-5p) novel signature has been found differentially expressed between controls and patients with migraine. Enrichment analysis showed that these pathways are closely associated with known migraine pathophysiology, which could lead to the first reliable epi ...
Conclusions: A 3-miRNA (miR-342-3p, miR-532-3p and miR-758-5p) novel signature has been found differentially expressed between controls and patients with migraine. Enrichment analysis showed that these pathways are closely associated with known migraine pathophysiology, which could lead to the first reliable epigenetic biomarker set. Further studies should be performed to validate these findings in a larger and more heterogeneous sample.
CGRP, Migraine, and Brain MRI in CADASIL: A Pilot Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36729391/
Migraine may forestall microangiopathy in CADASIL, though possibly independent of severity as measured by MRD. Interictal serum CGRP did not differ in our cohort suggesting CGRP may not be vital...
Conclusions: Migraine may forestall microangiopathy in CADASIL, though possibly independent of severity as measured by MRD. Interictal serum CGRP did not differ in our cohort suggesting CGRP may not be vital to migraine pathophysiology in CADASIL. Larger studies are needed to account for age differences.
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Huma Sheikh, CEO, NY Neurology Medicine, PCFebruary 16, 2023Very interesting.
Open-label trials for CGRP-targeted drugs in migraine prevention: A narrative review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36718044/
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Conclusions: The open-label study program for calcitonin gene-related peptide-targeted migraine preventives confirms the favorable safety and efficacy profile of these drugs over time. Treatment adherence appears higher than with previous unspecific migraine preventives. Real-world data and post-marketing surveillance studies may corroborate and complement open-label results.
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Huma Sheikh, CEO, NY Neurology Medicine, PCFebruary 16, 2023This is a good review.