Inpatient Constipation Among Migraine Patients Prescribed Anti-calcitonin Gene-Related Peptide Monoclonal Antibodies and Standard of Care Antiepileptic Drugs: A Retrospective Cohort Study in a United States Electronic Health Record Database - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36203078/
doi: 10.1007/s40122-022-00440-7. Online ahead of print. 1 Optum, 1325 Boylston Street, 11th Floor, Boston, MA, 02215, USA. [email protected]. 2 Optum, 1325 Boylston Street, 11th Floor, Boston, MA, 02215, USA. 3...
Conclusion: Patients initiating erenumab had similar risk of inpatient constipation within 90 days of treatment initiation versus patients initiating other CGRP mAbs, and lower risk versus patients initiating AEDs. These findings provide context to events observed during post-marketing surveillance.
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Huma Sheikh, CEO, NY Neurology Medicine, PCOctober 29, 2022That can be a common side effect.
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Dr HamidOctober 26, 2022Interesting article about Patients initiating erenumab and side Effects such as constipation
Rimegepant for the treatment of migraine | Published in Health Psychology Research
By Amnon A. Berger, Ariel Winnick & 13 more. It is a part of a growing arsenal in migraine treatment, and may present the silver bullet for treatment of this...
Conclusion/Relevance: Rimegepant, a second-generation gepant, has shown efficacy in several clinical trials in treating acute migraine. Ongoing trials are also evaluating its role in migraine prophylaxis, and results are promising. It is also generally safer for use than existing options, does not appear to increase the chance of developing chronic migraines, and carries a very tolerable side effects profile. It is a part of a growing arsenal in migraine treatment, and may present the silver bullet for treatment of this disease.
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Huma Sheikh, CEO, NY Neurology Medicine, PCOctober 29, 2022MOre medications acutely are needed.
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Dr HamidOctober 26, 2022Migraine is a common form of primary headache, affecting up to 1 in every 6 Americans.
Telemedicine for neurologic diseases: A systematic review and meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36256522/
doi: 10.1111/ene.15599. Online ahead of print. 1 Canary Islands Health Research Institute Foundation (FIISC), Tenerife, Spain. 2 Evaluation Unit (SESCS), Canary Islands Health Service (SCS), Tenerife, Spain. 3 The Spanish Network of Agencies for Health Technology Assessment and Services of the National Health System (RedETS), Spain.
Conclusions: Well-designed and executed RCTs are needed to confirm our findings on stroke and to have more scientific evidence available for the other neurologic diseases.
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Huma Sheikh, CEO, NY Neurology Medicine, PCOctober 29, 2022This is a great article.
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Dr HamidOctober 26, 2022Interesting article on review and effectiveness and safety of telemedicine
Assessment of the relative effectiveness of erenumab compared with onabotulinumtoxinA for the prevention of chronic migraine - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36189948/
Objective : To assess the available clinical and economic evidence of erenumab vs onabotulinumtoxinA for chronic migraine (CM) and present de-novo indirect treatment comparisons (ITCs) based on available clinical trial...
Conclusion: These findings suggest directional benefits (although not reaching the threshold of statistical significance) associated with erenumab vs onabotulinumtoxinA for the preventive treatment of CM. Evidence from this study may inform healthcare stakeholders in treatment selection and optimization for patients with CM.
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Dr HamidOctober 26, 2022Interesting article- to assess the available clinical and economic evidence of erenumab vs onabotulinumtoxinA for chronic migraine (CM)
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Huma Sheikh, CEO, NY Neurology Medicine, PCOctober 18, 2022Head to head are def needed.
Migraine as an inflammatory disorder with microglial activation as a prime candidate
Source : https://www.tandfonline.com/doi/abs/10.1080/01616412.2022.2129774?journalCode=yner20
ABSTRACT The lower threshold of neuronal hyperexcitability has been correlated with migraines for decades but as technology has progressed, it has now become conceivable to learn more about the migraine disease. Apart from the "cortical spreading depression" and "activation of the trigeminovascular system", inflammation has been increasingly recognized as a possible pathogenic process that may have the possibility to regulate the disease severity.
Results & Conclusion: Of 1136 articles found initially and screening of 1047 records, 47 studies were included for the final review. This review concluded that inflammation and microglial overexpression as the prime candidate, plays an important role in the modulation of migraine and are responsible for the progression toward chronification. Therefore, this increases the possibility of preventing migraine development and chronification by blocking microglia overexpression.
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Dr HamidOctober 26, 2022neuronal hyperexcitability has been correlated with migraines for decades but as technology has progressed, it has now become conceivable to learn more about the migraine disease
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Huma Sheikh, CEO, NY Neurology Medicine, PCOctober 18, 2022Interesting!