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Metformin Inhibits the Pathogenic Functions of AChR-specific B and Th17 Cells by Targeting miR-146a

Metformin Inhibits the Pathogenic Functions of AChR-specific B and Th17 Cells by Targeting miR-146a

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https://www.sciencedirect.com/science/article/abs/pii/S0165247822001195?via=ihub

We established a classical animal model of myasthenia gravis as the experimental basis for the study of miR-146a. * We found that miR-146a expressed differently in thymus, lymph nodes and spleen of rat model, and the expression of mR-146a in disease specific T and B cells was also in a cell dependent manner.


Conclusion/Relevance: We found that miR-146a expressed differently in thymus, lymph nodes and spleen of rat model, and the expression of mR-146a in disease specific T and B cells was also in a cell dependent manner. Pathological character of disease specific Th17 and B cells could be reversed by the metformin alternation of miR-146a levels in these cells, indicating the potential therapeutic target role of miR-146a in myasthenia gravis.