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Clinical characteristics of ocular myasthenia gravis and outcomes of secondary generalisation: a systematic review protocol

Objective We aim to systematically assess the clinical characteristics of ocular myasthenia gravis (OMG) and report on the proportion of patients who develop secondary generalised myasthenia gravis (SGMG). Introduction OMG ..... see more

Source : https://bmjopen.bmj.com/content/12/9/e060259


Objective: We aim to systematically assess the clinical characteristics of ocular myasthenia gravis (OMG) and report on the proportion of patients who develop secondary generalised myasthenia gravis (SGMG).

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Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients

Myasthenia Gravis (MG) is mediated by autoantibodies against acetylcholine receptors that cause loss of the receptors in the neuromuscular junction. Eculizumab, a C5-inhibitor, is the only approved treatment for MG ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2022.968206/full


Conclusion/Relevance: To enable identification of MG patients that are likely to respond to C7 inhibition, we developed a patient stratification assay and showed in a small cohort of MG patients (n=19) that 63% had significant complement activation and C7-dependent loss of AChRs in this in vitro set up. This study provides validation of C7 as a...

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Abdeg technology for the treatment of myasthenia gravis: efgartigimod drug experience

ABSTRACT Myasthenia gravis is characterized by fluctuating muscle weakness that improves with rest and worsens with effort or throughout the day. Efgartigimod is a human IgG1-derived Fc fragment modified at ..... see more

Source : https://www.tandfonline.com/doi/abs/10.1080/1744666X.2022.2106972?journalCode=ierm20


Expert Opinion: Efgartigimod was efficacious and safe for generalized myasthenia patients with AChR antibody-positive patients. These findings need to be confirmed in AChR antibody-negative patients, and long-term safety studies are currently ongoing.

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SARS-CoV-2 vaccination and new-onset myasthenia gravis: A report of 7 cases and review of the literature

Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction (NMJ). MG has an incidence of 30 per million/year in adults but is rarer (1-5 per million/year) in ..... see more

Source : https://www.nmd-journal.com/article/S0960-8966(22)00650-2/fulltext


Relevance: Here we report 7 cases of new-onset myasthenia gravis in timely association with SARS-CoV-2 vaccination, including the first paediatric case identified to date. We also reviewed the literature for other new-onset MG cases reported within 4 weeks of SARS-CoV-2 vaccination and discuss our findings in the context of altered...

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Neurological outcomes of extended thymectomy for thymomatous myasthenia gravis: Subxiphoid vs. trans-sternal approaches

BackgroundThe subxiphoid approach has been widely used recently. However, there is little data focusing on neurological outcomes in patients with thymomatous myasthenia gravis (MG) who underwent subxiphoid thoracoscopic thymectomy. see more

Source : https://www.frontiersin.org/articles/10.3389/fsurg.2022.973954/full


Conclusions: In patients with Masaoka stage I and II thymoma who underwent thymectomy, with tumor size less than 5 cm and thymomatous MG, age ≦48 years and the subxiphoid approach were associated with a rapid improvement in clinical status.

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Meaning: Treatment with rituximab can be considered early after onset of generalized myasthenia gravis to reduce the risk of disease worsening and/or need of additional therapies.

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Highlights from the 2022 American Association of Neuromuscular & Electrodiagnostic Medicine Annual Meeting

Neurologists, physical medicine and rehabilitation physicians, other allied health professionals, and researchers came together for the annual meeting of the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) to learn from one another through plenary sessions and workshops that focused on the management and treatment of neuromuscular diseases, including amyotrophic lateral sclerosis (ALS), muscular dystrophy, Duchenne muscular dystrophy, myasthenia gravis (MG), and spinal muscular atrophy. Click above for a summary of the last two days of the conference. We will follow this up with a post-conference wrap-up report soon.

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Highlights from the 2022 American Association of Neuromuscular & Electrodiagnostic Medicine Annual Meeting

The American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) annual meeting brought together neurologists, physical medicine and rehabilitation physicians, other allied health professionals, and researchers. Courses, plenary sessions, and workshops focused on the management and treatment of neuromuscular diseases including amyotrophic lateral sclerosis, muscular dystrophy, Duchenne muscular dystrophy, myasthenia gravis (MG), and spinal muscular atrophy. Click above for a summary of the first two days of the conference.

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Seronegative Ocular Myasthenia Gravis in an Older Woman With Transient Dizziness and Diplopia

Myasthenia gravis (MG) is a neuromuscular junction disease caused by an autoimmune response against cholinergic receptors. The challenge in diagnosing MG in older patients is the variety of symptoms and ..... see more

Source : https://www.cureus.com/articles/108462-seronegative-ocular-myasthenia-gravis-in-an-older-woman-with-transient-dizziness-and-diplopia


Conclusion/Relevance: We report a case of seronegative MG with the chief complaint of dizziness in a 91-year-old female. Despite the complicated clinical course, continuous clinical reasoning and testing can lead to appropriate diagnosis and treatment. As the dizziness symptoms in this older patient could not be explained by chronic or...

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Electrophysiologic evaluation of myasthenia gravis and its mimics: real-world experience with single-fiber electromyography

ABSTRACT In centers which routinely perform single fiber electromyography (SFEMG) for suspected myasthenia gravis (MG), the additional benefit of other neurophysiologic investigations and the frequency of myasthenia mimics has not ..... see more

Source : https://www.tandfonline.com/doi/abs/10.1080/21548331.2022.2125706?journalCode=ihop20


Conclusion: SFEMG can be abnormal in a number of myasthenia mimics, and routine nerve conduction studies and electromyography should always be undertaken. In centers where SFEMG is performed routinely for the investigation of suspected MG, extensive proximal repetitive nerve stimulation can be foregone without substantially affecting...

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Developing the health state classification system for a condition-specific preference-based measure for patients with myasthenia gravis - PubMed

doi: 10.1080/09638288.2022.2120096. Online ahead of print. 1 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China. 2 JC School of Public Health and Primary Care, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36102606/


Conclusions: Based on a solid process of development and consultations with clinical professionals and patients, a valid MG-specific preference-based measure, MGQoL-6D, was developed. Further research will estimate the local preference weight to support the MG-related cost–utility analysis.

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What are the pharmacotherapeutic considerations for the treatment of myasthenia gravis?

Myasthenia gravis (MG) is a rare neurological disorder characterized by the impairment of the normal neuromuscular transmission. The majority of patients display antibodies directed either against the acetylcholine receptor (AChR), ..... see more

Source : https://www.tandfonline.com/doi/full/10.1080/14656566.2022.2122710


Expert Opinion: The recent introduction and continuous investigation of novel drugs targeting different immunopathological mechanisms raise the expectation of finally changing the algorithm of immunosuppression in MG. There is in fact a great unmet need in MG for a more effective and better tolerated therapy which could relieve the double...

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Metformin Inhibits the Pathogenic Functions of AChR-specific B and Th17 Cells by Targeting miR-146a

We established a classical animal model of myasthenia gravis as the experimental basis for the study of miR-146a. * We found that miR-146a expressed differently in thymus, lymph nodes and ..... see more

Source : https://www.sciencedirect.com/science/article/abs/pii/S0165247822001195?via=ihub


Conclusion/Relevance: We found that miR-146a expressed differently in thymus, lymph nodes and spleen of rat model, and the expression of mR-146a in disease specific T and B cells was also in a cell dependent manner. Pathological character of disease specific Th17 and B cells could be reversed by the metformin alternation of miR-146a levels in...

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Pyridostigmine-induced coronary artery spasm in early-onset myasthenia gravis: a case presentation and review of the literature

We present a case of pyridostigmine-induced coronary artery spasm in a woman with early-onset myasthenia gravis (MG) who suffered from acute chest discomfort a few days after pyridostigmine dose up-titration. ..... see more

Source : https://casereports.bmj.com/content/15/9/e249819


Relevance: We present a case of pyridostigmine-induced coronary artery spasm in a woman with early-onset myasthenia gravis (MG) who suffered from acute chest discomfort a few days after pyridostigmine dose up-titration. Twelve-lead ECG demonstrated ST-segment elevation in inferior limb leads together with sinus arrest.

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Preview of the 2022 American Association of Neuromuscular & Electrodiagnostic Medicine Annual Meeting

This year’s American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) Annual Meeting is being held in Nashville, Tennessee, and runs from Sept. 21 to 24, 2022. The AANEM meeting includes four days of in-person lectures, hands-on workshops, and social events. Participants may also register to attend virtually. Click above for a detailed preview of the event.