The psychological benefits of neuropsychological assessment feedback as a psycho-educational therapeutic intervention: A randomized-controlled trial with cross-over in multiple sclerosis
ABSTRACT Evidence supporting the direct therapeutic benefits of neuropsychological assessment (NPA) feedback relies mostly upon post-feedback consumer surveys. This randomized-controlled trial with cross-over investigated the benefits of NPA feedback in ..... see more
Source : https://www.tandfonline.com/doi/abs/10.1080/09602011.2022.2047734?journalCode=pnrh20
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Conclusion: Despite lack of improvement in the RCT component at 1-week post-NPA feedback, the absence of deterioration at this time, in addition to significant improvements in perceived cognitive functioning, self-efficacy and mood at follow-up, together with high satisfaction ratings, all support NPA feedback as a safe psycho-educational...
Persistently reduced humoral and sustained cellular immune response from first to third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients - PubMed
In this longitudinal cohort we found no significant increased humoral or cellular response with administration of a third SARS-CoV-2 mRNA vaccination. These findings suggest the need for clinical strategies to ..... see more
Conclusion: In this longitudinal cohort we found no significant increased humoral or cellular response with administration of a third SARS-CoV-2 mRNA vaccination. These findings suggest the need for clinical strategies to include allowance of B cell reconstitution before repeat vaccination and/or provision of pre-exposure prophylactic...
Synthesis and biological evaluation of Artemisinin derivatives as potential MS agents
In this paper, a series of artemisinin derivatives were synthesized and evaluated. Studies have shown that IFN-γ produced by Th1 CD4+ T cells and IL-17A secreted by Th17 CD4+ T ..... see more
Source : https://www.sciencedirect.com/science/article/abs/pii/S0960894X22001585?via=ihub
Relevance: In this paper, a series of artemisinin derivatives were synthesized and evaluated. Studies have shown that IFN-γ produced by Th1 CD4 T cells and IL-17A secreted by Th17 CD4 T cells played critical roles in the treatment of multiple sclerosis. We used different concentrations of artemisinin derivatives to inhibit Th1 / Th17...
Evaluation of peripapillary and subfoveal choroidal vascularity index in patients with multiple sclerosis
Available online 16 March 2022, 102810 * Peripapillary and sub-foveal choroidal tissue can be visualized using spectral-domain optical coherence tomography (OCT) in the EDI (enhanced depth imaging) mode. * It ..... see more
Source : https://www.sciencedirect.com/science/article/abs/pii/S1572100022000990?via=ihub
Conclusion: PCVI and SFCVI scores were significantly lower in MS patients compared to healthy controls. PCVI scores of MS patients who had a history of ON were significantly lower than those of patients without a previous ON attack, as were SFCVI scores. We consider that evaluation of PCVI and SFCVI might be useful for monitoring ocular...
Association of Slowly Expanding Lesions on MRI With Disability in People With Secondary Progressive Multiple Sclerosis
Objectives: To explore the relationship between slowly expanding lesions (SELs) on MRI and disability in secondary progressive multiple sclerosis (SPMS). Methods: We retrospectively studied 345 patients with SPMS enrolled in ..... see more
Source : https://n.neurology.org/content/early/2022/03/11/WNL.0000000000200144
High prevalence of intrathecal IgA synthesis in multiple sclerosis patients - Scientific Reports
The detection of intrathecal IgA synthesis (IAS) in multiple sclerosis (MS) could be underestimated. To assess it, we develop a highly sensitive assay based on isoelectric focusing (IEF). 151 MS ..... see more
Conclusion/Relevance: Using IEF, MS patients showed higher percentage of IAS-IEF (43.00%) than the control group (16.98) (p = 0.001). The incidence was especially higher in patients with clinically isolated syndrome (66.00%). The new IFE demonstrated a higher percentage of IAS in MS patients than assumed in the past. The presence of...
A point-of-care diagnostic test for aquaporin-4 antibody seropositive neuromyelitis optica - PubMed
doi: 10.1016/j.msard.2022.103716. Online ahead of print. 1 Department of Neurology, Massachusetts General Hospital, Boston, MA, United States of America. 2 Department of Neurology, Massachusetts General Hospital, Boston, MA, United States ..... see more
A one year follow of patients with multiple sclerosis during COVID-19 pandemic: A cross-sectional study in Qom province, Iran
In December 2019, a cluster of unexplained pneumonia in Wuhan, China, penetrated borders and became a global pandemic. The current pandemic and the numerous unexplained issues regarding the post-pandemic phase, ..... see more
Source : https://www.msard-journal.com/article/S2211-0348(22)00227-9/fulltext
Conclusion:The present study showed a significant lower incidence of COVID-19 infection in MS patients. Except for clinical relapse, other demographic and MS characteristics, and DMT type were not associated with COVID-19 infection. In addition, COVID-19 vaccination reduced the risk of COVID-19 development, and the prognosis was favorable in...
Neurology's vital role in preventing unnecessary and potentially harmful pediatric studies
Abstract Regulatory authorities recognize two human populations: adults and children defined as see more
Source : https://www.tandfonline.com/doi/abs/10.1080/14737175.2022.2045953?journalCode=iern20
Expert opinion: Young patients with multiple sclerosis and other neurological diseases deserve studies with therapeutic intentions. “Pediatric” careers have emerged in academia, regulatory authorities, and pharmaceutical companies. Institutional Review Boards/ Ethics Committees should suspend questionable “pediatric” studies and reject...
Cannabinoid and endocannabinoid system: a promising therapeutic intervention for multiple sclerosis - Molecular Biology Reports
Multiple sclerosis (MS) is a chronic and complex neurodegenerative disease, distinguished by the presence of lesions in the central nervous system (CNS) due to exacerbated immunological responses that inflict oligodendrocytes ..... see more
Source : https://link.springer.com/article/10.1007/s11033-022-07223-5
Evolution of Anti-B Cell Therapeutics in Autoimmune Neurological Diseases - Neurotherapeutics
B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antigen-presenting cells facilitating antibody production but also as sensors, coordinators, and regulators ..... see more
Source : https://link.springer.com/article/10.1007/s13311-022-01196-w
Conclusion/Relevance: The paper summarizes basic aspects of B cell biology, discusses the roles of B cells in neurological autoimmunities, and highlights how the currently available or under development anti-B cell therapeutics exert their action in the wide spectrum and immunologically diverse neurological disorders. The efficacy of the...
Early predictive risk factors for dimethyl fumarate-associated lymphopenia in patients with multiple sclerosis
Delayed-release dimethyl fumarate (DMF; Tecfidera, Biogen, Weston, MA) is an oral disease-modifying therapy (DMT) approved for the treatment of adult patients with relapsing multiple sclerosis (RMS) (Tecfidera, 2014). During the ..... see more
Source : https://www.msard-journal.com/article/S2211-0348(22)00184-5/fulltext
Incidence, prevalence, and characteristics of heart failure among patients with multiple sclerosis: A systematic review and meta-analysis
Multiple sclerosis (MS) is the most common neurological autoimmune disease, whose symptoms often begin early in adulthood(Addy and Robin, 1981). It occurs due to progressive myelin degeneration within the central ..... see more
Source : https://www.msard-journal.com/article/S2211-0348(22)00180-8/fulltext
Conclusion: In conclusion, this study demonstrates that patients with MS are at an elevated risk of developing heart failure compared to the general population, which highlights the importance of regular and thorough checkups in PwMS in an effort to better detect any cardiovascular abnormality, dysfunction, or disease as soon as possible to...
Comorbidity in multiple sclerosis: Emphasis on patient-reported outcomes - PubMed
Comorbidity is a relevant issue in multiple sclerosis as half of people with MS report concomitant conditions. Hypertension, depression, and anxiety are especially prevalent in MS. In our study, comorbidity ..... see more
Conclusion: Comorbidity is a relevant issue in multiple sclerosis as half of people with MS report concomitant conditions. Hypertension, depression, and anxiety are especially prevalent in MS. In our study, comorbidity is associated with quality of life and fatigue, but not relapse rate. Depression and anxiety are independently associated with...
Hypogonadism in men with multiple sclerosis: Prevalence and clinical associations - PubMed
It has been hypothesized that multiple sclerosis (MS) has hormonal influences, and testosterone may have anti-inflammatory functions in this context. Given prior reports of lower testosterone levels in men with ..... see more
Highlights:
•No difference between multiple sclerosis patients without treatment and healthy people in terms of COVID-19 vaccine response.
•Multiple sclerosis patients on disease-modifying treatment have lower antibody responses than those without treatment.
•mRNA vaccine resulted in a more significant antibody response than an...
Single-nucleus RNA-seq of normal-appearing brain regions in relapsing-remitting vs. secondary progressive multiple sclerosis
Multiple sclerosis (MS) is an immune-mediated demyelinating disease that alters central nervous system (CNS) functions. Relapsing-remitting MS (RRMS) is the most common form, which can transform into secondary-progressive MS (SPMS) ..... see more
Source : https://www.biorxiv.org/content/10.1101/2022.01.10.475705v1
Notably, SPMS brains downregulated astrocytic sphingosine kinases (SPHK1/2) – the enzymes required to phosphorylate and activate the MS drug, fingolimod. This reduction was modeled with astrocyte-specific Sphk1/2 null mice in which fingolimod lost activity, supporting functionality of observed transcriptomic changes. These data provide an...
High or increasing serum NfL is predictive of impending multiple sclerosis relapses
With an expanding spectrum of disease-modifying treatments (DMTs) for patients with MS, the need for biomarkers that can identify patients at risk of impending disease activity who might benefit from ..... see more
Source : https://www.msard-journal.com/article/S2211-0348(22)00050-5/fulltext
Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis - PubMed
Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system (CNS) caused by CNS infiltration of peripheral immune cells, immune-mediated attack of the myelin sheath, neuroinflammation, ..... see more
PIGA1138-treatment, which increased neurosteroid allopregnanolone production, ameliorated all pathological biomarkers, while PIGA839, unable to activate neurosteroidogenesis in vivo, exerted only moderate/partial effects in MOG-EAE mice. Altogether, our results suggest that PIGA1138-based treatment may represent an interesting possibility to...
Predicting upper limb disability progression in primary progressive multiple sclerosis using machine learning and statistical methods
Multiple sclerosis (MS) is a heterogeneous immune-mediated disorder of the central nervous system, and primary progressive MS (PPMS) is characterized by insidious injury independent of clinical relapses from disease onset. ..... see more
Source : https://ieeexplore.ieee.org/abstract/document/9669665