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The psychological benefits of neuropsychological assessment feedback as a psycho-educational therapeutic intervention: A randomized-controlled trial with cross-over in multiple sclerosis

ABSTRACT Evidence supporting the direct therapeutic benefits of neuropsychological assessment (NPA) feedback relies mostly upon post-feedback consumer surveys. This randomized-controlled trial with cross-over investigated the benefits of NPA feedback in ..... see more

Source : https://www.tandfonline.com/doi/abs/10.1080/09602011.2022.2047734?journalCode=pnrh20

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Conclusion: Despite lack of improvement in the RCT component at 1-week post-NPA feedback, the absence of deterioration at this time, in addition to significant improvements in perceived cognitive functioning, self-efficacy and mood at follow-up, together with high satisfaction ratings, all support NPA feedback as a safe psycho-educational...

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Persistently reduced humoral and sustained cellular immune response from first to third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients - PubMed

In this longitudinal cohort we found no significant increased humoral or cellular response with administration of a third SARS-CoV-2 mRNA vaccination. These findings suggest the need for clinical strategies to ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35334278/


Conclusion: In this longitudinal cohort we found no significant increased humoral or cellular response with administration of a third SARS-CoV-2 mRNA vaccination. These findings suggest the need for clinical strategies to include allowance of B cell reconstitution before repeat vaccination and/or provision of pre-exposure prophylactic...

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Synthesis and biological evaluation of Artemisinin derivatives as potential MS agents

In this paper, a series of artemisinin derivatives were synthesized and evaluated. Studies have shown that IFN-γ produced by Th1 CD4+ T cells and IL-17A secreted by Th17 CD4+ T ..... see more

Source : https://www.sciencedirect.com/science/article/abs/pii/S0960894X22001585?via=ihub


Relevance: In this paper, a series of artemisinin derivatives were synthesized and evaluated. Studies have shown that IFN-γ produced by Th1 CD4 T cells and IL-17A secreted by Th17 CD4 T cells played critical roles in the treatment of multiple sclerosis. We used different concentrations of artemisinin derivatives to inhibit Th1 / Th17...

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Evaluation of peripapillary and subfoveal choroidal vascularity index in patients with multiple sclerosis

Available online 16 March 2022, 102810 * Peripapillary and sub-foveal choroidal tissue can be visualized using spectral-domain optical coherence tomography (OCT) in the EDI (enhanced depth imaging) mode. * It ..... see more

Source : https://www.sciencedirect.com/science/article/abs/pii/S1572100022000990?via=ihub


Conclusion: PCVI and SFCVI scores were significantly lower in MS patients compared to healthy controls. PCVI scores of MS patients who had a history of ON were significantly lower than those of patients without a previous ON attack, as were SFCVI scores. We consider that evaluation of PCVI and SFCVI might be useful for monitoring ocular...

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Association of Slowly Expanding Lesions on MRI With Disability in People With Secondary Progressive Multiple Sclerosis

Objectives: To explore the relationship between slowly expanding lesions (SELs) on MRI and disability in secondary progressive multiple sclerosis (SPMS). Methods: We retrospectively studied 345 patients with SPMS enrolled in ..... see more

Source : https://n.neurology.org/content/early/2022/03/11/WNL.0000000000200144


Conclusions: Definite SELs represent almost one third of T2 lesions in SPMS. They are associated with neurodegenerative MRI markers and related to clinical worsening, suggesting that they may contribute to disease progression and be a new target for therapeutic interventions.

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High prevalence of intrathecal IgA synthesis in multiple sclerosis patients - Scientific Reports

The detection of intrathecal IgA synthesis (IAS) in multiple sclerosis (MS) could be underestimated. To assess it, we develop a highly sensitive assay based on isoelectric focusing (IEF). 151 MS ..... see more

Source : https://www.nature.com/articles/s41598-022-08099-y


Conclusion/Relevance: Using IEF, MS patients showed higher percentage of IAS-IEF (43.00%) than the control group (16.98) (p = 0.001). The incidence was especially higher in patients with clinically isolated syndrome (66.00%). The new IFE demonstrated a higher percentage of IAS in MS patients than assumed in the past. The presence of...

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A point-of-care diagnostic test for aquaporin-4 antibody seropositive neuromyelitis optica - PubMed

doi: 10.1016/j.msard.2022.103716. Online ahead of print. 1 Department of Neurology, Massachusetts General Hospital, Boston, MA, United States of America. 2 Department of Neurology, Massachusetts General Hospital, Boston, MA, United States ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35247751/


Conclusion: This point-of-care AQP4-Ab testing method may become a pragmatic option to diagnose AQP4-Ab seropositive NMOSD in difficult-to-reach settings. This method should be confirmed with other testing parameters and field tested in new populations.

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A one year follow of patients with multiple sclerosis during COVID-19 pandemic: A cross-sectional study in Qom province, Iran

In December 2019, a cluster of unexplained pneumonia in Wuhan, China, penetrated borders and became a global pandemic. The current pandemic and the numerous unexplained issues regarding the post-pandemic phase, ..... see more

Source : https://www.msard-journal.com/article/S2211-0348(22)00227-9/fulltext


Conclusion:The present study showed a significant lower incidence of COVID-19 infection in MS patients. Except for clinical relapse, other demographic and MS characteristics, and DMT type were not associated with COVID-19 infection. In addition, COVID-19 vaccination reduced the risk of COVID-19 development, and the prognosis was favorable in...

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Expert opinion: Young patients with multiple sclerosis and other neurological diseases deserve studies with therapeutic intentions. “Pediatric” careers have emerged in academia, regulatory authorities, and pharmaceutical companies. Institutional Review Boards/ Ethics Committees should suspend questionable “pediatric” studies and reject...

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Cannabinoid and endocannabinoid system: a promising therapeutic intervention for multiple sclerosis - Molecular Biology Reports

Multiple sclerosis (MS) is a chronic and complex neurodegenerative disease, distinguished by the presence of lesions in the central nervous system (CNS) due to exacerbated immunological responses that inflict oligodendrocytes ..... see more

Source : https://link.springer.com/article/10.1007/s11033-022-07223-5


Relevance: In this review, we focused on the exacerbated immune attack on nerve cells and the role of the cannabinoids and its interaction with the ECS in CNS during MS pathology.

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Evolution of Anti-B Cell Therapeutics in Autoimmune Neurological Diseases - Neurotherapeutics

B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antigen-presenting cells facilitating antibody production but also as sensors, coordinators, and regulators ..... see more

Source : https://link.springer.com/article/10.1007/s13311-022-01196-w


Conclusion/Relevance: The paper summarizes basic aspects of B cell biology, discusses the roles of B cells in neurological autoimmunities, and highlights how the currently available or under development anti-B cell therapeutics exert their action in the wide spectrum and immunologically diverse neurological disorders. The efficacy of the...

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Early predictive risk factors for dimethyl fumarate-associated lymphopenia in patients with multiple sclerosis

Delayed-release dimethyl fumarate (DMF; Tecfidera, Biogen, Weston, MA) is an oral disease-modifying therapy (DMT) approved for the treatment of adult patients with relapsing multiple sclerosis (RMS) (Tecfidera, 2014). During the ..... see more

Source : https://www.msard-journal.com/article/S2211-0348(22)00184-5/fulltext


Conclusions: A pronounced reduction in ALCs early after initiation of DMF in MS patients is the best predictive risk factor for the subsequent development of significant lymphopenia.

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Incidence, prevalence, and characteristics of heart failure among patients with multiple sclerosis: A systematic review and meta-analysis

Multiple sclerosis (MS) is the most common neurological autoimmune disease, whose symptoms often begin early in adulthood(Addy and Robin, 1981). It occurs due to progressive myelin degeneration within the central ..... see more

Source : https://www.msard-journal.com/article/S2211-0348(22)00180-8/fulltext


Conclusion: In conclusion, this study demonstrates that patients with MS are at an elevated risk of developing heart failure compared to the general population, which highlights the importance of regular and thorough checkups in PwMS in an effort to better detect any cardiovascular abnormality, dysfunction, or disease as soon as possible to...

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Comorbidity in multiple sclerosis: Emphasis on patient-reported outcomes - PubMed

Comorbidity is a relevant issue in multiple sclerosis as half of people with MS report concomitant conditions. Hypertension, depression, and anxiety are especially prevalent in MS. In our study, comorbidity ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35123292/


Conclusion: Comorbidity is a relevant issue in multiple sclerosis as half of people with MS report concomitant conditions. Hypertension, depression, and anxiety are especially prevalent in MS. In our study, comorbidity is associated with quality of life and fatigue, but not relapse rate. Depression and anxiety are independently associated with...

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Hypogonadism in men with multiple sclerosis: Prevalence and clinical associations - PubMed

It has been hypothesized that multiple sclerosis (MS) has hormonal influences, and testosterone may have anti-inflammatory functions in this context. Given prior reports of lower testosterone levels in men with ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35123293/


Relevance: Given prior reports of lower testosterone levels in men with MS in archival serum samples, we evaluated the prevalence of hypogonadism in the clinical setting and its association with disability in men with MS.

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Highlights:
•No difference between multiple sclerosis patients without treatment and healthy people in terms of COVID-19 vaccine response.
•Multiple sclerosis patients on disease-modifying treatment have lower antibody responses than those without treatment.
•mRNA vaccine resulted in a more significant antibody response than an...

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Single-nucleus RNA-seq of normal-appearing brain regions in relapsing-remitting vs. secondary progressive multiple sclerosis

Multiple sclerosis (MS) is an immune-mediated demyelinating disease that alters central nervous system (CNS) functions. Relapsing-remitting MS (RRMS) is the most common form, which can transform into secondary-progressive MS (SPMS) ..... see more

Source : https://www.biorxiv.org/content/10.1101/2022.01.10.475705v1


Notably, SPMS brains downregulated astrocytic sphingosine kinases (SPHK1/2) – the enzymes required to phosphorylate and activate the MS drug, fingolimod. This reduction was modeled with astrocyte-specific Sphk1/2 null mice in which fingolimod lost activity, supporting functionality of observed transcriptomic changes. These data provide an...

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High or increasing serum NfL is predictive of impending multiple sclerosis relapses

With an expanding spectrum of disease-modifying treatments (DMTs) for patients with MS, the need for biomarkers that can identify patients at risk of impending disease activity who might benefit from ..... see more

Source : https://www.msard-journal.com/article/S2211-0348(22)00050-5/fulltext


Conclusion: We enumerate the risk of relapse associated with dynamic changes in sNfL. Both baseline and longitudinal change in sNfL may help identify patients who would benefit from early treatment optimisation.

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Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis - PubMed

Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system (CNS) caused by CNS infiltration of peripheral immune cells, immune-mediated attack of the myelin sheath, neuroinflammation, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35018577/



PIGA1138-treatment, which increased neurosteroid allopregnanolone production, ameliorated all pathological biomarkers, while PIGA839, unable to activate neurosteroidogenesis in vivo, exerted only moderate/partial effects in MOG-EAE mice. Altogether, our results suggest that PIGA1138-based treatment may represent an interesting possibility to...

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Predicting upper limb disability progression in primary progressive multiple sclerosis using machine learning and statistical methods

Multiple sclerosis (MS) is a heterogeneous immune-mediated disorder of the central nervous system, and primary progressive MS (PPMS) is characterized by insidious injury independent of clinical relapses from disease onset. ..... see more

Source : https://ieeexplore.ieee.org/abstract/document/9669665


To our knowledge, this is the first study to systematically evaluate ML models and statistical methods for predicting progression in PPMS using a well-characterized clinical trial cohort.