Neurofilament light chain as a surrogate candidate for disease activity in multiple sclerosis (LUMINOUS)-A meta-regression of randomized controlled trials - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41574448/
In MS, treatment effects on s/pNfL are moderately associated with therapeutic effects on ARR, MRI new/enlarging T2 lesions, and CDW, whereas no consistent association was observed with PBVC.
Meta-regression of randomized trials shows treatment-related reductions in serum or plasma neurofilament light chain moderately correlate with relapse rate, disability worsening, and MRI lesion activity, supporting its role as a disease activity biomarker.
Violence and multiple sclerosis: Towards an evidence-informed call to action in neurology - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41527696/
Violence is a global health concern with profound physical, psychological and social consequences. People with multiple sclerosis (MS) may experience sustained risk due to the intersection of chronic illness, disability,...
Review synthesizes emerging evidence on violence affecting people with multiple sclerosis, highlighting unmet research needs and advocating trauma-informed, case-finding approaches to improve recognition, response, and integration of violence-informed care into neurology services.
A review of multiple sclerosis: From pathophysiology to latest therapeutic advances - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41523333/
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration within the central nervous system (CNS). It predominantly affects women and young adults, with environmental and...
Review summarizes multiple sclerosis pathophysiology, disease phenotypes, diagnostic criteria, and current disease-modifying therapies, highlighting emerging remyelination and neuroprotective strategies relevant to relapsing and progressive disease management.
Review evaluates autologous hematopoietic stem cell transplantation for multiple sclerosis, highlighting sustained remission and higher NEDA rates in DMT-resistant RRMS, limited benefit in progressive disease, profile, timing, and conditioning considerations.
Autologous Stem Cell Transplantation for Multiple Sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41482159/
Multiple sclerosis (MS) is an autoimmune, inflammatory, and neurodegenerative disorder of the central nervous system, likely generated by an EBV infection with auto-antibodies targeting myelin antigens primarily through molecular mimicry....
Retinal nerve fiber layer thinning in multiple sclerosis: clinical implications, cognitive associations, and effects of disease-modifying therapies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41391056/
pRNFL thinning reflects disease severity and predicts cognitive decline in MS. Current DMTs provide limited retinal neuroprotection. These findings support the routine OCT-derived pRNFL monitoring and highlight the need for...
In Chinese multiple sclerosis patients, faster retinal nerve fiber layer thinning reflected disease severity and predicted cognitive decline, while baseline thickness and disease-modifying therapies showed limited prognostic or neuroprotective effects.