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Hypervigilance, Allostatic Load, and Migraine Prevention: Antibodies to CGRP or Receptor

Hypervigilance, Allostatic Load, and Migraine Prevention: Antibodies to CGRP or Receptor

Source : https://link.springer.com/article/10.1007/s40120-021-00250-7

Migraine involves brain hypersensitivity with episodic dysfunction triggered by behavioral or physiological stressors. During an acute migraine attack the trigeminal nerve is activated (peripheral sensitization). This leads to central sensitization with activation of the central pathways including the trigeminal nucleus caudalis, the trigemino-thalamic tract, and the thalamus.