Altered amygdala effective connectivity in migraine without aura: evidence from resting‐state fMRI with Granger causality analysis

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-021-01240-8

Background Granger causality analysis (GCA) has been used to investigate the pathophysiology of migraine. Amygdala plays a key role in pain modulation of migraine attack. However, the detailed neuromechanism remained to be elucidated. We applied GCA to explore the amygdala-based directional effective connectivity in migraine without aura (MwoA) and to determine the relation with clinical characteristics.