Slowly repeated evoked pain (SREP) as a central sensitization marker in episodic migraine patients

Source : https://www.nature.com/articles/s41598-021-84157-1

Migraine headache is a pain condition characterized by severe and recurrent unilateral head pain. Among other mechanisms, central pain sensitization processes seem to be involved in the disorder. An experimental protocol based on slowly repeated evoked pain (SREP) has been shown to indicate pain sensitization in fibromyalgia patients and differentiate these patients from healthy individuals and rheumatoid arthritis patients.