The de novo CACNA1A pathogenic variant Y1384C associated with hemiplegic migraine, early onset cerebellar atrophy and developmental delay leads to a loss of Cav2.1 channel function
Source : https://link.springer.com/article/10.1186/s13041-021-00745-2
CACNA1A pathogenic variants have been linked to several neurological disorders including familial hemiplegic migraine and cerebellar conditions. More recently, de novo variants have been associated with severe early onset developmental encephalopathies. CACNA1A is highly expressed in the central nervous system and encodes the pore-forming CaVα1 subunit of P/Q-type (Cav2.1) calcium channels.
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Huma Sheikh, CEO, NY Neurology Medicine, PCFebruary 24, 2021This is a good article that shows how migraine genes are related to other brain metabolic and other functions.