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Effects of estrogen and progesterone on the neurogenic inflammatory neuropeptides: implications for gender differences in migraine

Effects of estrogen and progesterone on the neurogenic inflammatory neuropeptides: implications for gender differences in migraine

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https://link.springer.com/article/10.1007/s00221-020-05923-7

Neurogenic inflammation including calcitonin gene-related peptide (CGRP) and substance-P (SP) release plays a pivotal role in migraine pathogenesis. Prevalence of migraine is ~ 3 folds higher in women than in men, but its underlying mechanisms remained unclear. We investigated the effects of female sex hormones estrogen and progesterone on CGRP and SP in in-vivo and ex-vivo in rats of both sexes.