Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36297301/
2022 Sep 27;15(10):1189. doi: 10.3390/ph15101189. 1 Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Glostrup, 2600 Copenhagen, Denmark. 2 Department of Neurorehabilitation/Traumatic Brain Injury, Rigshospitalet, 2100 Copenhagen, Denmark. Free PMC article Casper Emil Christensen et al. Pharmaceuticals (Basel). Free PMC article . 2022 Sep 27;15(10):1189. doi: 10.3390/ph15101189.
Conclusions: Human studies into the pathophysiological underpinnings of CGRP and PACAP in migraine are manifold and here we review the works investigating these neuropeptides in patients suffering from migraine in order to elucidate the background for developing new treatment options for this vastly disabling disorder.