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Role of endothelin in the pathophysiology of migraine: A new view on an old player

Role of endothelin in the pathophysiology of migraine: A new view on an old player

Source :

https://www.sciencedirect.com/science/article/abs/pii/S0143417922000610?via=ihub

There is cumulating evidence that endothelin-1 (ET-1) may play a role in migraine, however controversial findings still impede a conclusion to be drawn. Herein we tested the hypothesis that endothelin ETB receptors are major contributors to migraine-like responses.


Conclusion: Selective blockade of ETB receptors in the TG fully prevented the development of periorbital mechanical allodynia and photic sensitivity induced by CGRP, but ETA receptor blockade caused only a slight reduction of periorbital mechanical allodynia without affecting photic sensitivity. ETB receptor-operated mechanisms in the TG may contribute to migraine-like responses in female rats.