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Pregnant Patient Struggles with Recent Onset Migraines

A 31-year-old woman who is four months pregnant comes to your office complaining about recent onset headaches. These have started to occur ..... see more

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  • 2 weeks 5 days
    This case presents some challenges since the patient is pregnant which not only puts her at increased risk of ominous causes of headache but also limits testing and treatment. I Show More
  • from Doctor Unite 3 weeks 5 days
    test
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Pediatric Episodic Migraine with Aura: A Unique Entity?

Next Article in Journal Next Article in Special Issue Previous Article in Journal Previous Article in Special Issue You seem to have javascript disabled. Please note that many of the ..... see more

Source : https://www.mdpi.com/2227-9067/8/3/228/review_report

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  • 2 weeks 5 days
    This link is to reviewer and author comments but not to the article
  • 3 weeks 3 days
    This is an important study.
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TYPES OF HEADACHES - 2021.

TYPES OF HEADACHES @Neuralgroover According to the World Health Organization, headaches are a global problem, affecting people of all races, income levels, and regional areas. Headache disorders impact about 50% ..... see more

Source : https://virtualheadachespecialist.com/types-of-headaches/

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  • 2 weeks 5 days
    This post highlights the prevalence of headaches and describes different types of headaches. I would caution that sinus headaches are still overdiagnosed usually by non-neurologists and frequently lead to Show More
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The migraine signature study: Methods and baseline results - PubMed

Among patients with migraine in a large health system, those who were also cared for in neurology were more likely to receive both acute and preventive medication migraine orders than ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33368248/

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  • 2 weeks 5 days
    This is an important study because of the large study population size with several important take home points: 1. Migraine patients have more comorbidities than patients without migraines (not news) 2. Migraine Show More
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One sided headache with congestion, runny nose, and red tearing eye.

ONE-SIDED HEADACHE WITH CONGESTED RUNNY NOSE, OR RED, TEARING AND SWOLLEN EYE. 5 REASONS WHY. @Neuralgroover BACKGROUND TRIGEMINAL AUTONOMIC CEPHALALGIAS (TACs) CLUSTER HEADACHE Do you have a one-sided headache, left-sided ..... see more

Source : https://virtualheadachespecialist.com/one-sided-headache-with-congestion-red-eye/

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TENSION HEADACHES - 2021.

TENSION HEADACHES @Neuralgroover Tension headaches are the most common types of headaches that people suffer. In fact, tension headaches afflict three out of every four Americans from time to time, ..... see more

Source : https://virtualheadachespecialist.com/tension-headaches/

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Headache chart of headache locations for different types of headaches!

HEADACHE CHART AND HEADACHE LOCATIONS FOR DIFFERENT TYPES OF HEADACHES - 2021. @Neuralgroover I can picture it now. You're sitting there late at night breaking out into a cold sweat, ..... see more

Source : https://virtualheadachespecialist.com/headache-chart-and-headache-locations-for-different-types-of-headaches/

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Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen.

Objective Our objective is to explore whether blood-cerebrospinal fluid (CSF) barrier biomarkers differ in episodic migraine (EM) or chronic migraine (CM) from controls. Background Reports of blood-brain barrier and blood-cerebrospinal ..... see more

Source : https://europepmc.org/article/med/33724462

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  • 3 weeks 3 days
    This can help to determine important biomarkers.
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Is Palinopsia in Migraineurs a Phenomenon of Impaired Habituation of Visual Cortical Neurons? - Jayantee Kalita, Usha K. Misra, Mritunjai Kumar, Robin Bansal, Ravi Uniyal, 2021

Palinopsia in migraine has been reported recently, which may be due to the dysexcitability of visual cortical neurons. In this cross-sectional study, we report the correlation of neuronal dysexcitability with ..... see more

Source : https://doi.org/10.1177/1550059421991707

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Recurrent vestibulopathy: are cVEMP, oVEMP and inner ear MRI useful to distinguish patients with Menière's disease and vestibular migraine?

Purpose The aim of this study was to assess the rate of endolymphatic hydrops (EH) on MRI and the rate of otolithic dysfunction with cVEMP and oVEMP, in patients with ..... see more

Source : https://link.springer.com/article/10.1007/s00405-021-06716-6

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Migraine-like headaches associated with nickel allergy requiring removal of atrial septal defect closure device

There is a deficit of literature regarding the association between nickel allergy-induced symptoms and implanted devices. This report describes a case of nickel allergy causing debilitating migraine-like symptoms, failing to ..... see more

Source : https://link.springer.com/article/10.1007/s12055-021-01155-8

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Familial hemiplegic migraine type 2 due to a novel missense mutation in ATP1A2

Background The mechanisms of genotype-phenotype interaction in Familiar Hemiplegic migraine type 2 (FHM2) are still far from clear. Different ATP1A2 mutations have been described, with a spectrum of phenotypes ranging ..... see more

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-021-01221-x

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  • 1 month
    There are likely a number of mutations that can lead to a migraine phenotype.
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Interictal Photophobia and Phonophobia Are Related to the Presence of Aura and High Frequency of Attacks in Patients with Migraine

Background: Despite that photophobia and phonophobia are well-known symptoms related to migraine, it is unclear whether they affect daily life activities during the headache-free period. Objective: To evaluate the interictal ..... see more

Source : https://doi.org/10.3390/app11062474

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  • 1 month
    This is interesting, in chronic migraine it would make sense since there is chronicfication of the nervous system, but I wonder why migraine with aura would have this inter-ictal phenomenon.
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Effect of Occipital Nerve Stimulation (ONS) on the Orbicularis Oculi Reflex Triggered by a Standardized Air Flow in Patients with Chronic Migraine-A Prospective, Randomized, Interventional Study

Introduction Occipital nerve stimulation (ONS) is a specific form of peripheral neuromodulation used in the treatment of chronic pain disorders. A particular field of application is in the therapy of ..... see more

Source : https://link.springer.com/article/10.1007/s40122-021-00242-3

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  • 1 month 2 weeks
    The entire nervous systems is linked and provides feedback to each other, interesting study.
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Slowly repeated evoked pain (SREP) as a central sensitization marker in episodic migraine patients

Migraine headache is a pain condition characterized by severe and recurrent unilateral head pain. Among other mechanisms, central pain sensitization processes seem to be involved in the disorder. An experimental ..... see more

Source : https://www.nature.com/articles/s41598-021-84157-1

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Aimovig®: One dose, once a month, designed to work 24/7 all month long to help prevent migraine in adults

In a usability study of the SureClick® autoinjector among adult migraine patients (N = 204):

  • 96% found the autoinjector easy to use2,†
  • 93% would recommend the autoinjector to other patients2,†

Aimovig® is an anti-CGRP therapy that includes one monthly dose designed to work all month long to help prevent migraine.

Click here for resources to help your Aimovig patients, including those you have started through telemedicine.

204 autoinjector-naïve adult migraine patients were evaluated in a usability study of the Aimovig SureClick® single-dose autoinjector by performing a simulated injection. Percentages were derived from a combination of patients who stated that they completely agree or somewhat agree on a 5-point Likert scale.2

Expand +

INDICATION

Aimovig® (erenumab-aooe) is indicated for the preventive treatment of migraine in adults.

IMPORTANT SAFETY INFORMATION

Contraindication: Aimovig® is contraindicated in patients with serious hypersensitivity to erenumab-aooe or to any of the excipients. Reactions have included anaphylaxis and angioedema.

Hypersensitivity Reactions: Hypersensitivity reactions, including rash, angioedema, and anaphylaxis, have been reported with Aimovig® in post marketing experience.  Most reactions were not serious and occurred within hours of administration, although some occurred more than one week after administration.  If a serious or severe reaction occurs, discontinue Aimovig® and initiate appropriate therapy. 

Constipation with Serious Complications: Constipation with serious complications has been reported following the use of Aimovig® in the postmarketing setting.  There were cases that required hospitalization, including cases where surgery was necessary.  The onset of constipation was reported after the first dose in a majority of these cases, but patients also reported later on in treatment.  Aimovig® was discontinued in most reported cases.  Constipation was one of the most common (up to 3%) adverse reactions reported in clinical studies.

Monitor patients treated with Aimovig® for severe constipation and manage as clinically appropriate.  Concurrent use of medications associated with decreased gastrointestinal motility may increase the risk for more severe constipation and the potential for constipation-related complications.

Hypertension: Development of hypertension and worsening of pre-existing hypertension have been reported following the use of Aimovig® in the postmarketing setting. Many of the patients had pre-existing hypertension or risk factors for hypertension. There were cases requiring pharmacological treatment and, in some cases, hospitalization. Hypertension may occur at any time during treatment but was most frequently reported within seven days of dose administration. In the majority of the cases, the onset or worsening of hypertension was reported after the first dose. Aimovig® was discontinued in many of the reported cases.

Monitor patients treated with Aimovig® for new-onset hypertension, or worsening of pre-existing hypertension, and consider whether discontinuation of Aimovig® is warranted if evaluation fails to establish an alternative etiology.

Adverse Reactions: The most common adverse reactions in clinical studies (≥ 3% of Aimovig®-treated patients and more often than placebo) were injection site reactions and constipation.

Please see accompanying Aimovig® full Prescribing Information

References: 1. Aimovig® (erenumab-aooe) Prescribing Information. Thousand Oaks, CA: Amgen Inc; 2020. 2. Mead J, et al. Patient Reported Ease of Use with Disposable Autoinjector in Individuals with Migraine. Patient Preference and Adherence. 2020:14 1137-1144.

© 2020 Amgen Inc. All rights reserved. USA-334-84118   09/20

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Waking Up With Headaches: 6 Types of Wake Up Headaches.

WAKING UP WITH HEADACHES: 6 TYPES OF WAKE UP HEADACHES. @Neuralgroover WAKE UP HEADACHE Do you frequently wake up with a headache? This is a common feature with several types ..... see more

Source : https://virtualheadachespecialist.com/wake-up-headaches-why-you-are-waking-up-with-headaches/

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  • 1 month 3 weeks
    This is a good review, it is important to distinguish between waking up with a headache and waking up because of a headache, which can sometimes be more worrisome. Show More
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Calcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects

Migraine is the second largest cause of years lost to disability globally among all diseases, with a worldwide prevalence over 1 billion. Despite the global burden of migraine, few classes ..... see more

Source : https://jnnp.bmj.com/content/early/2021/01/25/jnnp-2020-324674.abstract

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Why Patients Do Not Comply With Headache Diaries?

Background: Headache calendars are part of good clinical practice in headache clinics. However, patients' compliance is rather variable. We aim to identify factors associated with poor compliance. Methods: Consecutive patients ..... see more

Source : https://www.researchsquare.com/article/rs-152653/v1

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  • 1 month 3 weeks
    This is a helpful finding, I try to get my patients to keep calendars but it can be difficult.
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Relationship between non-headache symptoms and right to left shunt in episodic migraine. A single-center cross-sectional study,Journal of Clinical Neuroscience - X-MOL

The relationship between right to left shunt (RLS) and non-headache symptoms (NHS) in episodic migraine is unknown. This study aimed to investigate the incidence and classification of RLS in episodic ..... see more

Source : https://www.x-mol.com/paper/1354517570827722752

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  • 1 month 3 weeks
    Interesting study, but I wonder if closing PFO are helpful?