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Interrelations between migraine-like headache and persistent post-traumatic headache attributed to mild traumatic brain injury: a prospective diary study

Persistent post-traumatic headache (PTH) is a common sequela of mild traumatic brain injury (TBI) and retrospective assessments have found a migraine-like phenotype to be very frequent. This has raised a ..... see more

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-01202-6

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  • 1 month
    In general, we treat the phenotype of post traumatic headaches. As this study shows, the most common phenotype is migraine with a mixture of tension type headaches in some Show More
  • 1 month 1 week
    There is def overlap between the two entities.
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Position Paper on Post-Traumatic Headache: The Relationship Between Head Trauma, Stress Disorder, and Migraine

Traumatic brain injury (mTBI) is a major public health concern, with mild TBI (mTBI) constituting the vast majority of the injuries. Post-traumatic headache (PTH) is one of the most frequent ..... see more

Source : https://link.springer.com/article/10.1007/s40122-020-00220-1

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  • 1 month
    This is a consensus position paper from authors across Europe that highlights the need for better definition of post traumatic headache to inform methodology of clinical trials of this entity Show More
  • 1 month
    Interesting paper, it would be good to see if post traumatic patients do respond to cGRP inhibitors
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Menière's disease

Menière's disease causes paroxysmal rotatory vertigo, due to endolymphatic hydrops, an accumulation of endolymph in the endolymphatic space of the labyrinth. Its major symptoms are attacks of rotatory vertigo lasting ..... see more

Source : https://pn.bmj.com/content/early/2020/11/27/practneurol-2020-002734.abstract

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  • 1 month
    This is a good review highlighting that the vertigo associated with Meniere's can last hours (not just minutes) and that the attacks become less frequent over time but there are Show More
  • 1 month
    This can be a difficult condition to treat, good review on this disease.
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Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study

To explore the possible concurrent brain functional and structural alterations in patients with migraine without aura (MwoA) patients compared to healthy subjects (HS). Seventy-two MwoA patients and forty-six HS were ..... see more

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-01203-5

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  • 1 month
    Interesting that the morphology of the brain changes in several regions of the brain in those with migraines (loss of tissue) but the functional changes occur in other areas of Show More
  • 1 month
    This study shows that the entire brain is involved in migraine. It is truly a disease that is all over the brain.
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How does the brain change in chronic migraine? Developing disease biomarkers,Cephalalgia - X-MOL

Background Validated chronic migraine biomarkers could improve diagnostic, prognostic, and predictive abilities for clinicians and researchers, as well as increase knowledge on migraine pathophysiology. Objective The objective of this narrative ..... see more

Source : https://www.x-mol.com/paper/1336821075974152192?recommendPaper=5694863

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Investigation of the plasma copeptin level in cases with childhood migraine

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33295228/

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  • 1 month
    Interesting but the positive predictive value of copeptin is fairly low. The study does suggest that stress (oxidative and other) may be a factor with childhood migraines. It Show More
  • 1 month
    cannot get access to the article.
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Cerebral fractional amplitude of low-frequency fluctuations may predict headache intensity improvement following acupuncture treatment in migraine patients

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33258357/

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  • 1 month
    interesting point that may hep point to how acupuncture is working.
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Interventional Procedures in Episodic Migraine

Migraine is a common disorder which in many cases can be adequately treated with medications. However, there are some patients who may either not respond to medications or have contraindications ..... see more

Source : https://link.springer.com/article/10.1007/s11916-020-00909-0

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  • 1 month 1 week
    I hope the evidence for nerve blocks is enough for insurance companies to start paying for it.
  • 1 month 2 weeks
    Good review of available data to support use of nerve blocks, TPI and Botox emphasizing that the data is limited and often conflicting. However, interesting study showing benefit of Show More
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Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin

While anecdotal evidence suggests that select 5-hydroxytryptamine 2A (5-HT2A) receptor ligands, including psilocybin, may have long-lasting therapeutic effects after limited dosing in headache disorders, controlled investigations are lacking. In an ..... see more

Source : https://link.springer.com/article/10.1007/s13311-020-00962-y

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  • 1 month 1 week
    This should be studied further but promising so far.
  • 1 month 2 weeks
    Preliminary data showing mild to moderate benefit of psilocybin in migraine but this needs to be further studied and viewed with caution given potential of long term side effects
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Risk and Resilience Factors Impacting Treatment Compliance and Functional Impairment among Adolescents Participating in an Outpatient Interdisciplinary Pediatric Chronic Pain Management Program

Recurrent pain is a common experience in childhood and adolescence and can result in significant disability in youth, including poor quality of life, school absences, and reduced social activities. Evidence ..... see more

Source : https://www.mdpi.com/2227-9067/7/11/247/htm

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  • 1 month 1 week
    This is usually rarely used but if efficaicous, it should be used more often.
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Experience of Migraine, its Severity, and Perceived Efficacy of Treatments among Cannabis Users,Complementary Therapies in Medicine - X-MOL

Objectives As the legal and cultural landscape surrounding cannabis use in the United States continues to evolve, more Americans are turning to cannabis to self-medicate a number of ailments, including ..... see more

Source : https://www.x-mol.com/paper/1330012132126924800

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  • 1 month 1 week
    We need to start finding ways to give this medication in a safe way.
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Migraine Frequency Decrease Following Prolonged Medical Cannabis Treatment: A Cross-Sectional Study

Background: Medical cannabis (MC) treatment for migraine is practically emerging, although sufficient clinical data are not available for this indication. This cross-sectional questionnaire-based study aimed to investigate the associations between ..... see more

Source : https://www.mdpi.com/2076-3425/10/6/360

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  • 1 month 1 week
    This is interesting emergent treatment, although we need to find ways to prescribe these that are safe and reliable.
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Impact of Neck and/or Shoulder Pain on Headache

As neck and/or shoulder pain (NSP) frequently occur together with tension-type headache (TTH) and migraine, we explored how concomitant NSP affects perceived treatment responses to an analgesic. An anonymous survey ..... see more

Source : https://www.preprints.org/manuscript/202011.0631/v1

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  • 1 month 1 week
    neck pain is very frequent with migraine and a large part of the migraine cycle. It is important to look for this in and treat it, trigger points or physical Show More
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Migraine and sleep disorders: a systematic review

Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs. The existence of a ..... see more

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-01192-5

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  • 1 month 2 weeks
    Sleep is often a major issue for migraineurs and should be explored by clinicians. This excellent review points out that insomnia is common in those with migraine and is Show More
  • 2 months
    Sleep and Migraine are intimately connected.
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The AHS recommends anti-CGRPs for patients who fail 2 or more oral preventives1

To learn more about patient resources to help your patients that you have prescribed Aimovig®, please visit our website for healthcare professionals.
View the full Prescribing Information

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INDICATION

Aimovig® (erenumab-aooe) is indicated for the preventive treatment of migraine in adults.

IMPORTANT SAFETY INFORMATION

Contraindication: Aimovig® is contraindicated in patients with serious hypersensitivity to erenumab-aooe or to any of the excipients.  Reactions have included anaphylaxis and angioedema.

Hypersensitivity Reactions: Hypersensitivity reactions, including rash, angioedema, and anaphylaxis, have been reported with Aimovig® in post marketing experience.  Most reactions were not serious and occurred within hours of administration, although some occurred more than one week after administration.  If a serious or severe reaction occurs, discontinue Aimovig® and initiate appropriate therapy. 

Constipation with Serious Complications: Constipation with serious complications has been reported following the use of Aimovig® in the postmarketing setting.  There were cases that required hospitalization, including cases where surgery was necessary.  The onset of constipation was reported after the first dose in a majority of these cases, but patients also reported later on in treatment. Aimovig® was discontinued in most reported cases.  Constipation was one of the most common (up to 3%) adverse reactions reported in clinical studies.

Monitor patients treated with Aimovig® for severe constipation and manage as clinically appropriate.  Concurrent use of medications associated with decreased gastrointestinal motility may increase the risk for more severe constipation and the potential for constipation-related complications.

Hypertension: Development of hypertension and worsening of pre-existing hypertension have been reported following the use of Aimovig® in the postmarketing setting. Many of the patients had pre-existing hypertension or risk factors for hypertension. There were cases requiring pharmacological treatment and, in some cases, hospitalization. Hypertension may occur at any time during treatment but was most frequently reported within seven days of dose administration. In the majority of the cases, the onset or worsening of hypertension was reported after the first dose. Aimovig® was discontinued in many of the reported cases.

Monitor patients treated with Aimovig® for new-onset hypertension, or worsening of pre-existing hypertension, and consider whether discontinuation of Aimovig® is warranted if evaluation fails to establish an alternative etiology.

Adverse Reactions: The most common adverse reactions in clinical studies (≥ 3% of Aimovig®-treated patients and more often than placebo) were injection site reactions and constipation.

Please see the link to the Aimovig® full Prescribing Information above.

© 2020 Amgen Inc. All rights reserved. USA-334-84150

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[Related risk factors of PET/CT detected coronary microvascular disease in patients with chest pain and no obstructive coronary artery disease].

Objective: To explore the related factors of the coronary microvascular disease (CMD) diagnosed with positron emission tomography(PET)/CT in patients with chest pain and without obstructive coronary artery disease (NOCA). Methods: ..... see more

Source : https://europepmc.org/article/med/33210866

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Rosacea and Neurological Comorbidities

Nita Katarina Frifelt Wienholtz Jacob Pontoppidan Thyssen Alexander Egeberg Part of the Updates in Clinical Dermatology book series (UCD) Rosacea is a chronic inflammatory skin disorder, which seems to have ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-52097-7_9

38-year-old male presents with intractable headaches

History of present illness: A 38-year-old male in excellent physical condition presents with a five-year history of intractable headaches, occurring with ..... see more

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  • from Generation NP 1 month 4 weeks
    Sounds like Emgality would be a good step if he can afford it. I would like to know more about family history and what other meds have been tried /failed. Show More
  • 1 month 4 weeks
    While the history says the headaches are 'intractable' we really do not know anything about frequency, i.e., migraine or headache days per month, so another alternative would be small Show More
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Differential Expression of Cytokine-Coding Genes among Migraine Patients with and without Aura and Normal Subjects

Migraine is a prevalent disorder in humans and represents one of the top 10 causes of years lived with disability. Several genetic and environmental factors are involved in the pathobiology ..... see more

Source : https://link.springer.com/article/10.1007/s12031-020-01745-y

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  • 2 months
    These cytokine expressions must also play a role in how migraine patients are reacting to COVID-19.