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Modulation of the Somatosensory Blink Reflex in the Peripersonal Space Is Defective in Episodic Migraine

Modulation of the Somatosensory Blink Reflex in the Peripersonal Space Is Defective in Episodic Migraine

Source : https://academic.oup.com/painmedicine/advance-article-abstract/doi/10.1093/pm/pnz328/5709920

AbstractObjective. In migraine, there is an altered behavior of patients during the attack and an altered connectivity in the cortical structures modulating an

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Acute treatment of migraine in adults - UpToDate

Source : https://www.uptodate.com/contents/acute-treatment-of-migraine-in-adults?search=TOPROL

The pathophysiology, clinical manifestations, and diagnosis of the migraine are also discussed separately. (See "Pathophysiology, clinical manifestations, and diagnosis of migraine in adults".)

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WVU Today | Cell-phone-sized device that stimulates nerve in neck may prevent migraine

WVU Today | Cell-phone-sized device that stimulates nerve in neck may prevent migraine

Source : https://wvutoday.wvu.edu/stories/2020/01/23/cell-phone-sized-device-that-stimulates-nerve-in-neck-may-prevent-migraine

Could applying a cell-phone-sized device to your neck three times a day prevent migraine attacks? WVU researcher Umer Najib thinks it might. In a new clinical trial, he's testing how .....

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White Matter Changes in Chronic and Episodic Migraine: A Diffusion Tensor Imaging Study - PubMed

White Matter Changes in Chronic and Episodic Migraine: A Diffusion Tensor Imaging Study - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/31898478-white-matter-changes-in-chronic-and-episodic-migraine-a-diffusion-tensor-imaging-study/

These findings suggest global white matter structural differences between episodic migraine and chronic migraine. Patients with chronic migraine could present axonal integrity impairment in the first months of chronic migraine .....

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ICHD-3 is significantly more specific than ICHD-3 beta for diagnosis of migraine with aura and with typical aura

ICHD-3 is significantly more specific than ICHD-3 beta for diagnosis of migraine with aura and with typical aura

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1072-2

In the emergency room, distinguishing between a migraine with aura and a transient ischemic attack (TIA) is often not straightforward and mistakes can be harmful to both the patient and .....

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How do you know if your episodic migraine patient with 5 migraine days/month is a candidate for an anti-CGRP treatment?

The American Headache Society issued a statement regarding the criteria for the initiation of anti-CGRP mAbs for migraine prevention:


Patient is ≥18 years old and medication is prescribed by a licensed medical professional


  • 4-7 headache days per month: Patients (with or without aura) should consider anti-CGRP treatment option if they 1) have failed at least 2 prior preventatives and 2) suffer from at least moderate disability (MIDAS > 11, HIT-6 > 50).

  • 8-14 headache days per month: Patients (with or without aura) should consider an anti-CGRP treatment option if they have failed at least 2 other preventatives.

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Knowing the AHS guidelines, how would you determine if a patient with episodic migraine with 5 migraine days/month is a candidate for anti-CGRP mAbs treatment as a preventive option?


CGRP = calcitonin gene-related peptide
mAbs = monoclonal antibodies
MIDAS = Migraine Disability Assessment
HIT-6 = six-item Headache Impact Test


Reference: American Headache Society. Headache. 2018; 59:1-18.
USA-334-82766

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This is a 35 y/o woman who presents to the office with a 7 year history of headaches that started out perimenstrually but over the last 2 years, she notes .....

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A 17-year-old patient arrived with the complaint of a chronic headache. She did have light sensitivity, and she also had some trouble with loud noises. The patient had been in .....

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Mapping migraine to a common brain network

Mapping migraine to a common brain network

Source : https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awz405/5699253

Abstract. Inconsistent findings from migraine neuroimaging studies have limited attempts to localize migraine symptomatology. Novel brain network mapping techn

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Cognitive effects of onabotulinumtoxinA in chronic migraine

Cognitive effects of onabotulinumtoxinA in chronic migraine

Source : https://neurologyopen.bmj.com/content/2/1/e000014

Background Chronic migraine is a disabling condition, often associated with comorbidities including cognitive dysfunction, anxiety and depression. It is unclear whether cognitive complaints are associated with the underlying migraine pathophysiological .....

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Development and Implementation of the Integrative Toolbox for Headache Management

Development and Implementation of the Integrative Toolbox for Headache Management

Source : https://doi.org/10.1111/head.13743

Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....

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PRIME PubMed | The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysi

PRIME PubMed | The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysi

Source : https://www.unboundmedicine.com/medline/citation/31924166/The_epidemiology_of_headaches_among_patients_with_epilepsy

Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases .....

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Role of Interventional Therapies for Migraine and Headache: Onabotulinum Toxin A, Stimulators, and Nerve Blocks

Role of Interventional Therapies for Migraine and Headache: Onabotulinum Toxin A, Stimulators, and Nerve Blocks

Source : https://themedicalroundtable.com/article/role-interventional-therapies-migraine-and-headache-onabotulinum-toxin-stimulators-and-nerve

Dr. David Dodick from Mayo Clinic, Phoenix, AZ moderated the topic "Role of Interventional Therapies for Migraine and Headache: Onabotulinum Toxin A, Stimulators, and Nerve Blocks" with Drs.

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The Effect Of Selective Neck Muscle Release Techniques On Clinical Indicators of Patients with Migraine Headache: A Randomized Controlled Trial

The Effect Of Selective Neck Muscle Release Techniques On Clinical Indicators of Patients with Migraine Headache: A Randomized Controlled Trial

Source : http://rehabilitationj.uswr.ac.ir/browse.php?a_id=2622&sid=1&slc_lang=en

Objective Subjects with migraine headache often have stiff posture, especially in the head and neck. Also, these patients often have reduced cervical range of motion, faulty posture, forward head posture, .....

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Cost of chronic and episodic migraine patients in continuous treatment for two years in a tertiary level headache Centre

Cost of chronic and episodic migraine patients in continuous treatment for two years in a tertiary level headache Centre

Source : https://link.springer.com/article/10.1186/s10194-019-1068-y

Migraine is one of the most common neurological diseases and an estimated 1.04 billion people worldwide have been diagnosed with migraine. Available data suggest that migraine is world widely associated .....

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TRPM8 genetic variant is associated with chronic migraine and allodynia.

TRPM8 genetic variant is associated with chronic migraine and allodynia.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31842742

J Headache Pain. 2019 Dec 16;20(1):115. doi: 10.1186/s10194-019-1064-2.

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Nightly sleep duration, fragmentation, and quality and daily risk of migraine

Nightly sleep duration, fragmentation, and quality and daily risk of migraine

Source : https://n.neurology.org/content/early/2019/12/16/WNL.0000000000008740

Objective To test the hypotheses that insufficient duration, high fragmentation, and poor sleep quality are temporally associated with migraine onset on the day immediately following the sleep period (day 0) .....

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Migraine progression in subgroups of migraine based on comorbidities

Migraine progression in subgroups of migraine based on comorbidities

Source : https://n.neurology.org/content/93/24/e2224

Objective To test the hypothesis that statistically defined subgroups of migraine (based on constellations of comorbidities and concomitant conditions; henceforth comorbidities), previously identified using Chronic Migraine Epidemiology and Outcomes (CaMEO) .....

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Nightly sleep duration, fragmentation, and quality and daily risk of migraine

Nightly sleep duration, fragmentation, and quality and daily risk of migraine

Source : https://n.neurology.org/content/early/2019/12/16/WNL.0000000000008740

Objective To test the hypotheses that insufficient duration, high fragmentation, and poor sleep quality are temporally associated with migraine onset on the day immediately following the sleep period (day 0) .....