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Sixty-Year-Old Man With Debilitating Daily Migraines

A 60-year-old male with a 20 year history of daily migraines comes to you for new options for pain management. Due to ..... see more

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Influence of headache pain intensity and frequency on migraine-related disability in chronic migraine patients treated with OnabotulinumtoxinA

There is a need to establish which are the more relevant headache-related outcomes that have an impact on our patient's lives to accurately evaluate treatment response in daily clinical practice. ..... see more

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-01157-8

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Evaluation of 2‐Hour Post‐Dose Efficacy of Lasmiditan for the Acute Treatment of Difficult‐to‐Treat Migraine Attacks

Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information ..... see more

Source : https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.13897?af=R

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Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization

Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarization. Sleep disorders ..... see more

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-01155-w

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Understanding What People With Migraine Consider to be Important Features of Migraine Tracking: An Analysis of the Utilization of Smartphone‐Based Migraine Tracking With a Free‐Text Feature

Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information ..... see more

Source : https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.13851

Huma Sheikh Commented on a Post
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35 y/o woman presents with headaches that are unilateral (but can change sides), associated with light and noise sensitivity. The headaches are associated with nausea. When she has a headache, she has trouble functioning at work and home. Patient reports headache frequency to be approximately 9-10 per month. Her neurologic exam, imaging and funduscopic exam were normal. She is not overweight but sleeps poorly.

Patient was diagnosed with migraine and given education on sleep hygiene and migraine preventive treatment. She was started on amitriptyline. At her recheck appointment, patient reported that amitriptyline did help her sleep, but did not significantly improve her migraine headaches. Amitriptyline was stopped and replaced with topiramate. At her recheck appointment, it was determined that although her migraine is down to 5-6 episodes per month (this means more than 1 episode per week), she continues to have an impact on her daily activities.

What would you try next for migraine prevention? Propranolol, an anti-CGRP monoclonal antibody, or another preventative? Why?

Aimovig STC #2 - image edit-1



1. American Headache Society. The American Headache Society Position Statement on integrating new migraine treatments into clinical practice. Headache. 2019;59(1)1-18.

CGRP = calcitonin gene-related peptide

USA-334-83586 07/20

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A few of the many treatments that we have for migraine, with so many options, do you have a protocol that you follow or ways to choose one over the ..... see more

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Prevalence of Migraine and Neuropathic Pain in Rheumatic Diseases

To investigate the physiopathology of pain in chronic inflammatory rheumatic diseases (CIRDs), we assessed the prevalence of migraine and neuropathic pain in 499 patients with CIRDs. We studied 238 patients ..... see more

Source : https://www.mdpi.com/2077-0383/9/6/1890

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Migraine start, course and features over the cycle of combined hormonal contraceptive users with menstrual migraine - temporal relation to bleeding and hormone withdrawal: a prospective diary-based study

Many studies have described the features of menstrually-related migraines (MRM) in the natural cycle and the efficacy of prevention. MRM in combined hormonal contraceptive (CHC) users has scarcely been researched. ..... see more

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-01150-1

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Serum Levels of Allopregnanolone, Progesterone and Testosterone in Menstrually-Related and Postmenopausal Migraine: A Cross-Sectional Study - PubMed

Decreased GABAergic inhibition, due to low allopregnanolone serum levels, could contribute to menstrually-related migraine and persistence of migraine after menopause. For the management of these disorders, a rise in the ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32588652/

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Cranial Autonomic Symptoms of Migraine in Japan: Prospective Study of 373 Migraine Patients at a Tertiary Headache Center

Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information ..... see more

Source : https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.13888

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Twenty-Seven-Year-Old Woman With Uncontrolled Migraines

A 27-year-old woman presents to you with a history of migraines since she was 12. Her mother and sister also had migraines. She currently ..... see more

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Patients with migraine have the option of an anti-CGRP that is proven to reduce monthly migraine days

Aimovig® (erenumab-aooe) is indicated for the preventive treatment of migraine in adults

Meet Dayna, age 36

Before Aimovig®
Dayna had ≈ 8-12 monthly migraine days

With Aimovig®
Dayna experienced ≥50% reduction in monthly migraine days, with some weeks migraine-free, which has made a real difference for Dayna and the time she spends with those around her. 

Aimovig® made a real difference in Dayna’s life. If you have patients like Dayna, don’t wait to see what Aimovig® can do for them.
Learn what more migraine-free days can mean for your patients


Individual results may vary.
Please see Aimovig® full Prescribing Information

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IMPORTANT SAFETY INFORMATION
Contraindication:
Aimovig® is contraindicated in patients with serious hypersensitivity to erenumab-aooe or to any of the excipients. Reactions have included anaphylaxis and angioedema.

Hypersensitivity Reactions: Hypersensitivity reactions, including rash, angioedema, and anaphylaxis, have been reported with Aimovig® in post marketing experience. Most reactions were not serious and occurred within hours of administration, although some occurred more than one week after administration. If a serious or severe reaction occurs, discontinue Aimovig® and initiate appropriate therapy.

Constipation with Serious Complications: Constipation with serious complications has been reported following the use of Aimovig® in the postmarketing setting. There were cases that required hospitalization, including cases where surgery was necessary. The onset of constipation was reported after the first dose in a majority of these cases, but patients also reported later on in treatment. Aimovig® was discontinued in most reported cases. Constipation was one of the most common (up to 3%) adverse reactions reported in clinical studies.

Monitor patients treated with Aimovig® for severe constipation and manage as clinically appropriate. Concurrent use of medications associated with decreased gastrointestinal motility may increase the risk for more severe constipation and the potential for constipation-related complications.

Adverse Reactions: The most common adverse reactions in clinical studies (≥ 3% of Aimovig®-treated patients and more often than placebo) were injection site reactions and constipation.

© 2019 Amgen Inc. All rights reserved. USA-334-83291

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Are there any good resources to get the latest evidence on what causes aura? I know we have moved away from the blood vessel theory or is hypoperfusion still ..... see more

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Genetics of migraine aura: an update

de Boer Irene; The Journal of Headache and Pain : Official Journal of the Italian Society for the Study of Headaches; Milano Vol. 21, Iss. 1, (Dec 2020). DOI:10.1186/s10194-020-01125-2 Terwindt, ..... see more

Source : https://search.proquest.com/openview/8f65d9703a6787e43bd33c59e553cb11/1?pq-origsite=gscholar&cbl=43392

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Vestibular migraine and benign paroxysmal positional vertigo, close presentation dilemma

Background: Not only an association between benign paroxysmal positional vertigo (BPPV) and migraine have been recognized in the literature, but also, there are close similarities between BPPV and vestibular migraine ..... see more

Source : https://doi.org/10.1080/00016489.2020.1770857

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Significant Incidental Brain Magnetic Resonance Imaging Findings in Migraine Headache Patients: Retrospective Cross-Sectional Study | Request PDF

Request PDF | Significant Incidental Brain Magnetic Resonance Imaging Findings in Migraine Headache Patients: Retrospective Cross-Sectional Study | Background Migraine is one of the most common complaints encountered in neurology ..... see more

Source : https://www.researchgate.net/publication/342270570_Significant_Incidental_Brain_Magnetic_Resonance_Imaging_Findings_in_Migraine_Headache_Patients_Retrospective_Cross-Sectional_Study

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Validation of an algorithm for automated classification of migraine and tension-type headache attacks in an electronic headache diary

This study evaluates the accuracy of an automated classification tool of single attacks of the two major primary headache disorders migraine and tension-type headache used in an electronic headache diary. see more

Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-01139-w

Should We Adapt the Prescription Criteria for Specific Treatments for Migraine Due to the COVID‐19 Pandemic?

Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information ..... see more

Source : https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.13880

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(PDF) Machine learning approach to predict medication overuse in migraine patients

Machine learning (ML) is largely used to develop automatic predictors in migraine classification but automatic predictors for medication overuse (MO) in migraine are still in their infancy. Thus, to understand ..... see more

Source : https://www.researchgate.net/publication/342147597_Machine_learning_approach_to_predict_medication_overuse_in_migraine_patients