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Effects of estrogen and progesterone on the neurogenic inflammatory neuropeptides: implications for gender differences in migraine

Neurogenic inflammation including calcitonin gene-related peptide (CGRP) and substance-P (SP) release plays a pivotal role in migraine pathogenesis. Prevalence of migraine is ~ 3 folds higher in women than in men, but ..... see more

Source : https://link.springer.com/article/10.1007/s00221-020-05923-7

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Melatonin for Acute Treatment of Migraine in Children and Adolescents: A Pilot Randomized Trial

Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information ..... see more

Source : https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.13934

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Patterns of Perceived Stress Throughout the Migraine Cycle: A Longitudinal Cohort Study Using Daily Prospective Diary Data

Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information ..... see more

Source : https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.13943?af=R

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Relation of Statin Use Prior to Admission to Severity and Recovery Among COVID-19 Inpatients - Am. J. Cardiol. - X-MOL

X-MOL提供的期刊论文更新,The American Journal of Cardiology--Relation of Statin Use Prior to Admission to Severity and Recovery Among COVID-19 Inpatients,Lori B. Daniels; Amy M. Sitapati; Jing Zhang; Jingjing Zou; Quan M. Bui; ..... see more

Source : https://www.x-mol.com/paper/1306396406905540608

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Woman With "Stress Headaches"

A 30-year-old woman presents to your clinic with what she terms as "stress headaches." She first had onset of these headaches when she was in ..... see more

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Searching for Predictors of Migraine Chronification: a Pilot Study of 1911A>G Polymorphism of TRPV1 Gene in Episodic Versus Chronic Migraine

Transient receptor potential vanilloid type 1 (TRPV1) receptors activated by heat and capsaicin are expressed in trigeminal nociceptive neurons and implicated in the generation of migraine pain. Genetic studies suggested ..... see more

Source : https://link.springer.com/article/10.1007/s12031-020-01683-9

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Altered Serum Levels of Renin‐Angiotensin System Markers in Migraine

To compare the serum levels of renin‐angiotensin system (RAS) components between patients with migraine and healthy controls, and to evaluate whether these levels are associated with migraine severity. We hypothesized ..... see more

Source : https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.13949

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[Novel migraine treatment with CGRP-related monoclonal antibodies] - PubMed

Migraine is a common and debilitating neurological disorder characterized by recurrent attacks of moderate to severe throbbing headache accompanied by nausea, vomiting and photophobia/phonophobia. Because of its high prevalence, migraine ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32893246/

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Assessment of cervical and ocular vestibular evoked myogenic potentials in migraine patients

Patients suffering from vestibular migraine (VM) are known to have various vestibular test abnormalities interictally and ictally. Recently, vestibular evoked myogenic potentials (VEMPs) have become accepted as a valid method ..... see more

Source : https://ejo.springeropen.com/articles/10.1186/s43163-020-00017-1

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What Comes Next: A Patient Case With Preventive Migraine Treatment

Sam suffers from 8 migraine days/month, interfering with work and family life. She tried propranolol 80 mg/day for 2 months but her migraine did not improve. She then tried topiramate 100 mg/day ..... see more

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Aimovig®: One dose, once a month, designed to work 24/7 all month long to help prevent migraine in adults

In a usability study of the SureClick® autoinjector among adult migraine patients (N = 204):

  • 96% found the autoinjector easy to use2,†
  • 93% would recommend the autoinjector to other patients2,†

Aimovig® is an anti-CGRP therapy that includes one monthly dose designed to work all month long to help prevent migraine.

Click here for resources to help your Aimovig patients, including those you have started through telemedicine.

204 autoinjector-naïve adult migraine patients were evaluated in a usability study of the Aimovig SureClick® single-dose autoinjector by performing a simulated injection. Percentages were derived from a combination of patients who stated that they completely agree or somewhat agree on a 5-point Likert scale.2

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INDICATION

Aimovig® (erenumab-aooe) is indicated for the preventive treatment of migraine in adults.

IMPORTANT SAFETY INFORMATION

Contraindication: Aimovig® is contraindicated in patients with serious hypersensitivity to erenumab-aooe or to any of the excipients. Reactions have included anaphylaxis and angioedema.

Hypersensitivity Reactions: Hypersensitivity reactions, including rash, angioedema, and anaphylaxis, have been reported with Aimovig® in post marketing experience.  Most reactions were not serious and occurred within hours of administration, although some occurred more than one week after administration.  If a serious or severe reaction occurs, discontinue Aimovig® and initiate appropriate therapy. 

Constipation with Serious Complications: Constipation with serious complications has been reported following the use of Aimovig® in the postmarketing setting.  There were cases that required hospitalization, including cases where surgery was necessary.  The onset of constipation was reported after the first dose in a majority of these cases, but patients also reported later on in treatment.  Aimovig® was discontinued in most reported cases.  Constipation was one of the most common (up to 3%) adverse reactions reported in clinical studies.

Monitor patients treated with Aimovig® for severe constipation and manage as clinically appropriate.  Concurrent use of medications associated with decreased gastrointestinal motility may increase the risk for more severe constipation and the potential for constipation-related complications.

Hypertension: Development of hypertension and worsening of pre-existing hypertension have been reported following the use of Aimovig® in the postmarketing setting. Many of the patients had pre-existing hypertension or risk factors for hypertension. There were cases requiring pharmacological treatment and, in some cases, hospitalization. Hypertension may occur at any time during treatment but was most frequently reported within seven days of dose administration. In the majority of the cases, the onset or worsening of hypertension was reported after the first dose. Aimovig® was discontinued in many of the reported cases.

Monitor patients treated with Aimovig® for new-onset hypertension, or worsening of pre-existing hypertension, and consider whether discontinuation of Aimovig® is warranted if evaluation fails to establish an alternative etiology.

Adverse Reactions: The most common adverse reactions in clinical studies (≥ 3% of Aimovig®-treated patients and more often than placebo) were injection site reactions and constipation.

Please see accompanying Aimovig® full Prescribing Information

References: 1. Aimovig® (erenumab-aooe) Prescribing Information. Thousand Oaks, CA: Amgen Inc; 2020. 2. Mead J, et al. Patient Reported Ease of Use with Disposable Autoinjector in Individuals with Migraine. Patient Preference and Adherence. 2020:14 1137-1144.

© 2020 Amgen Inc. All rights reserved. USA-334-84118   09/20

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SUPPLEMENTS AND NATURAL TREATMENTS FOR MIGRAINE PREVENTION, EVERYTHING YOU NEED TO KNOW. - Headache Diagnosis Tool

SUPPLEMENTS AND NATURAL TREATMENTS FOR MIGRAINE PREVENTION, EVERYTHING YOU NEED TO KNOW. @Neuralgroover Worldwide, migraine affects more than 10-12% of the population, with approximately 700 million migraineurs estimated worldwide.1 It ..... see more

Source : https://virtualheadachespecialist.com/supplements-and-natural-treatments-for-migraine-prevention-everything-you-need-to-know/

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PREVENTATIVE MIGRAINE TREATMENT - WHEN TO START, WHICH TO START, AND WHEN TO STOP. - Headache Diagnosis Tool

PREVENTATIVE MIGRAINE TREATMENT - WHEN TO START, WHICH TO START, AND WHEN TO STOP. @Neuralgroover BACKGROUND Migraine is a very disruptive disorder to have to deal with. It interferes with ..... see more

Source : https://virtualheadachespecialist.com/preventative-migraine-treatment-when-to-start-which-to-start-and-when-to-stop/

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MENSTRUAL MIGRAINE TREATMENT TIPS AND CONTRACEPTION STROKE RISK. - Headache Diagnosis Tool

MENSTRUAL MIGRAINE TREATMENT TIPS AND CONTRACEPTION STROKE RISK. @Neuralgroover BACKGROUND Migraine is estimated to effect about 18% of women and 6% of men. That is a 3:1 ratio. Much of ..... see more

Source : https://virtualheadachespecialist.com/menstrual-migraine-treatment-tips-and-contraception-stroke-risk/

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Blog of Hot Topics and Headache Hacks - Headache Diagnosis Tool

BATTLE OF THE MONOCLONAL ANTIBODY CGRP ANTAGONISTS: AIMOVIG vs. AJOVY vs. EMGALITY vs. VYEPTI. WHAT ARE THE DIFFERENCES AND WHICH IS BEST FOR YOU? @Neuralgroover New blog coming soon, stay ..... see more

Source : https://virtualheadachespecialist.com/blog/

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The Spectrum of Response to Erenumab in Patients With Episodic Migraine and Subgroup Analysis of Patients Achieving ≥50%, ≥75%, and 100% Response

Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information ..... see more

Source : https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.13929

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Intravenous sodium valproate for acute migraine in the emergency department: A meta‐analysis

The role of intravenous sodium valproate (iVPA) in acute migraine attack has not been completely established. The aim of this updated review was to evaluate the efficacy and safety of ..... see more

Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13325?af=R