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Mapping migraine to a common brain network
Source : https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awz405/5699253
Abstract. Inconsistent findings from migraine neuroimaging studies have limited attempts to localize migraine symptomatology. Novel brain network mapping techn
Cognitive effects of onabotulinumtoxinA in chronic migraine
Source : https://neurologyopen.bmj.com/content/2/1/e000014
Background Chronic migraine is a disabling condition, often associated with comorbidities including cognitive dysfunction, anxiety and depression. It is unclear whether cognitive complaints are associated with the underlying migraine pathophysiological .....
Development and Implementation of the Integrative Toolbox for Headache Management
Source : https://doi.org/10.1111/head.13743
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
_a_systematic_review_and_meta-analysis.
PRIME PubMed | The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysi
Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases .....
Role of Interventional Therapies for Migraine and Headache: Onabotulinum Toxin A, Stimulators, and Nerve Blocks
Dr. David Dodick from Mayo Clinic, Phoenix, AZ moderated the topic "Role of Interventional Therapies for Migraine and Headache: Onabotulinum Toxin A, Stimulators, and Nerve Blocks" with Drs.
The Effect Of Selective Neck Muscle Release Techniques On Clinical Indicators of Patients with Migraine Headache: A Randomized Controlled Trial
Source : http://rehabilitationj.uswr.ac.ir/browse.php?a_id=2622&sid=1&slc_lang=en
Objective Subjects with migraine headache often have stiff posture, especially in the head and neck. Also, these patients often have reduced cervical range of motion, faulty posture, forward head posture, .....
Cost of chronic and episodic migraine patients in continuous treatment for two years in a tertiary level headache Centre
Source : https://link.springer.com/article/10.1186/s10194-019-1068-y
Migraine is one of the most common neurological diseases and an estimated 1.04 billion people worldwide have been diagnosed with migraine. Available data suggest that migraine is world widely associated .....
TRPM8 genetic variant is associated with chronic migraine and allodynia.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31842742
J Headache Pain. 2019 Dec 16;20(1):115. doi: 10.1186/s10194-019-1064-2.
Nightly sleep duration, fragmentation, and quality and daily risk of migraine
Source : https://n.neurology.org/content/early/2019/12/16/WNL.0000000000008740
Objective To test the hypotheses that insufficient duration, high fragmentation, and poor sleep quality are temporally associated with migraine onset on the day immediately following the sleep period (day 0) .....
Migraine progression in subgroups of migraine based on comorbidities
Source : https://n.neurology.org/content/93/24/e2224
Objective To test the hypothesis that statistically defined subgroups of migraine (based on constellations of comorbidities and concomitant conditions; henceforth comorbidities), previously identified using Chronic Migraine Epidemiology and Outcomes (CaMEO) .....
Nightly sleep duration, fragmentation, and quality and daily risk of migraine
Source : https://n.neurology.org/content/early/2019/12/16/WNL.0000000000008740
Objective To test the hypotheses that insufficient duration, high fragmentation, and poor sleep quality are temporally associated with migraine onset on the day immediately following the sleep period (day 0) .....
Most Bothersome Symptom in Persons With Migraine: Results From the Migraine in America Symptoms and Treatment (MAST) Study
Source : https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.13708
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
Aspirin in the Treatment and Prevention of Migraine Headaches: Possible Additional Clinical Options for Primary Healthcare Providers.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31712099
Am J Med. 2019 Nov 9. pii: S0002-9343(19)30966-0. doi: 10.1016/j.amjmed.2019.10.023. [Epub ahead of print] Review
A Brief Look at Urgent Care Visits for Migraine: The Care Received and Ideas to Guide Migraine Care in this Proliferating Medical Setting.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31802490
OBJECTIVE: There has been a rise in urgent care centers throughout the country over the past 10 years, leading to an increase in patients accessing medical care in these locations. .....
Migraine and the risk of all‐cause dementia, Alzheimer's disease, and vascular dementia: A prospective cohort study in community‐dwelling older adults
Source : https://onlinelibrary.wiley.com/doi/abs/10.1002/gps.5180
Dementia is the most common neurological disease in older adults; headaches, including migraines, are the most common neurological disorder across all ages. The objective of this study was to explore .....
A new link between migraines, opioid overuse may be key to treating pain
Source : https://www.sciencedaily.com/releases/2019/11/191120131307.htm
About 10% of the world population suffers from migraine headaches, according to the National Institute of Neurological Disorders and Stroke. To alleviate migraine pain, people are commonly treated with opioids. .....
Alterations of individual thalamic nuclei volumes in patients with migraine
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1063-3
The aim of this study is to investigate the alterations of thalamic nuclei volumes and the intrinsic thalamic network in patients with migraine. We enrolled 35 patients with migraine without .....
Propofol for Treatment of Acute Migraine in the Emergency Department: A Systematic Review.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31621134
OBJECTIVES: Propofol has not been extensively studied as an acute migraine therapy; however, based on the limited evidence from outpatient and inpatient settings, propofol has been proposed as an option .....
Appraisal of Headache Trigger Patterns Using Calendars
Source : https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.13703
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
Effect of genetic liability to migraine on coronary artery disease and atrial fibrillation: a Mendelian randomization study.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31661179
Eur J Neurol. 2019 Oct 29. doi: 10.1111/ene.14111. [Epub ahead of print]
Differences in clinical features of cluster headache between drinkers and nondrinkers in Japan
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224407
Objective Alcohol has been recognized as the main trigger for a cluster headache attack, but clinical features to distinguish between cluster headache in drinkers and nondrinkers are unclear. Thus, the .....
Development of a Prospective Real-World Data Clinical Registry of Children and Adolescents With Migraine
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
Wearing Off Effect of OnabotulinumtoxinA Near the End of Treatment Cycle for Chronic Migraine: A 4-Year Clinical Experience
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
Acute vestibular migraine treatment with noninvasive vagus nerve stimulation
Source : https://n.neurology.org/content/93/18/e1715
Objective To report on the benefits of noninvasive vagus nerve stimulation (nVNS) on acute vestibular migraine (VM) treatment. Methods This was a retrospective chart review of patients with VM treated .....
A new link between migraines, opioid overuse may be key to treating pain
Source : https://today.uic.edu/a-new-link-between-migraines-opioid-overuse-may-be-key-to-treating-pain
About 10% of the world population suffers from migraine headaches, according to the National Institute of Neurological Disorders and Stroke. To alleviate migraine pain, people are commonly treated with opioids. .....
Dynamic functional connectivity of the migraine brain: a resting-state functional magnetic resonance imaging study.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31408050
Pain. 2019 Dec;160(12):2776-2786. doi: 10.1097/j.pain.0000000000001676.
Paranasal sinus air suction for immediate pain relief of acute migraine - a randomized, double blind pilot study.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31646974
BACKGROUND: Migraine is a primary headache disorder, which cause significant disability in adolescence. This double blind, randomized clinical trial assessed the immediate effects of suction of paranasal sinus air during .....
Allodynia in Menstrually Related Migraine: Score Assessment by Allodynia Symptom Checklist (ASC-12).
Source : https://www.ncbi.nlm.nih.gov/pubmed/31637701
OBJECTIVE: The aim of this study was to compare the allodynia score in headache attacks related and not related to menstruation in women diagnosed with menstrually related migraine without aura. .....
Food Insecurity and Migraine Are Linked in Young Adults:... : Neurology Today
Article In Brief In a research letter, investigators reported that young adults who lack reliable access to affordable, nutritious food had a significantly higher chance of being diagnosed with migraine. .....
Early Onset of Efficacy With Fremanezumab for the Preventive Treatment of Chronic Migraine.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31675102
OBJECTIVE: To assess the onset of efficacy for fremanezumab in chronic migraine by evaluating pain-related clinical measures at different time points. BACKGROUND: Faster onset of efficacy of preventive treatments could .....
Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1058-0
Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. Accumulating evidence is pointing toward malfunctioning of brainstem structures, i.e., the red nucleus (RN) and substantia nigra (SN), .....
Effect of genetic liability to migraine on coronary artery disease and atrial fibrillation: a Mendelian randomization study
Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.14111
Iyas Daghlas Corresponding Author E-mail address: iyas_daghlas@hms.harvard.edu https://orcid.org/0000-0001-8735-284X Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115 USA Center for Genomic Medicine, .....
Subgrouping Factors influencing Migraine Intensity in Women: A Semi-automatic Methodology based on Machine Learning and Information Geometry.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31677218
Pain Pract. 2019 Nov 1. doi: 10.1111/papr.12854. [Epub ahead of print]
Interictal Hyperperfusion in the Higher Visual Cortex in Patients With Episodic Migraine.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31680242
Headache. 2019 Nov;59(10):1808-1820. doi: 10.1111/head.13646. Epub 2019 Nov 4.
Efficacy, Tolerability, and Safety of DFN‐15 (Celecoxib Oral Solution, 25 mg/mL) in the Acute Treatment of Episodic Migraine: A Randomized, Double‐Blind, Placebo‐Controlled Study
Source : https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.13663
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
Acute vestibular migraine treatment with noninvasive vagus nerve stimulation
Source : https://n.neurology.org/content/early/2019/09/25/WNL.0000000000008388
Objective To report on the benefits of noninvasive vagus nerve stimulation (nVNS) on acute vestibular migraine (VM) treatment. Methods This was a retrospective chart review of patients with VM treated .....
The appropriate dosing of erenumab for migraine prevention after multiple preventive treatment failures: a critical appraisal
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1054-4
Erenumab, a fully human monoclonal antibody directed against the calcitonin gene-related peptide receptor, was approved for the prevention of episodic (EM) or chronic migraine (CM) at the monthly dose of .....
Effects of Non‐invasive Brain Stimulation on Headache Intensity and Frequency of Headache Attacks in Patients With Migraine: A Systematic Review and Meta‐Analysis
Source : https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.13645
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
Headache Outcomes After Treatment of Unruptured Intracranial Aneurysm: A Systematic Review and Meta-Analysis.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31607243
Stroke. 2019 Oct 14:STROKEAHA119026864. doi: 10.1161/STROKEAHA.119.026864. [Epub ahead of print]
Enhancing Outpatient Dihydroergotamine Infusion With Interdisciplinary Care to Treat Refractory Pediatric Migraine: Preliminary Outcomes From the Comprehensive Aggressive Migraine Protocol (“CAMP”)
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
Intravenous Magnesium Sulfate to Treat Acute Headaches in the Emergency Department: A Systematic Review.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31566727
Headache. 2019 Sep 30. doi: 10.1111/head.13648. [Epub ahead of print] Review
Allodynia in Menstrually Related Migraine: Score Assessment by Allodynia Symptom Checklist (ASC‐12)
Source : https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.13677
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
Advances in genetics of migraine
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1017-9
Migraine is a complex neurovascular disorder with a strong genetic component. There are rare monogenic forms of migraine, as well as more common polygenic forms; research into the genes involved .....
Acute vestibular syndrome associated with anti-GQ1b antibody
Source : https://n.neurology.org/content/93/11/e1085
Objectives To delineate the clinical features and ocular motor findings in acute vestibular syndrome (AVS) associated with anti-GQ1b antibodies. Methods We reviewed 90 patients with positive serum anti-GQ1b antibody in .....
Lamotrigine can lead to remission of visual snow symptoms
Source : https://www.aao.org/editors-choice/lamotrigine-can-lead-to-remission-of-visual-snow-s
Comprehensive Ophthalmology, Neuro-Ophthalmology/Orbit Researchers evaluated pharmacologic treatment options for visual snow and reported the prevalence of comorbid diseases. The authors examined the medical charts of 58 patients with a diagnosis .....
Why Newer Migraine Blockers Fail Some Patients : Neurology Today
Article In Brief Research in an animal model of headache suggests that different underlying mechanisms at work in migraine may explain why some calcitonin gene-related peptide inhibitors, such as fremanezumab, .....
Fremanezumab versus placebo for migraine prevention in patients with documented failure to up to four migraine preventive medication classes (FOCUS): a randomised, double-blind, placebo-controlled, phase 3b trial.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31427046
Lancet. 2019 Sep 21;394(10203):1030-1040. doi: 10.1016/S0140-6736(19)31946-4. Epub 2019 Aug 16.
Discontinuation of Acute Prescription Medication for Migraine: Results From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31544244
Headache. 2019 Sep 22. doi: 10.1111/head.13642. [Epub ahead of print]
Characterization of Familial and Sporadic Migraine.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31544229
BACKGROUND: It is unknown whether clinical parameters differ between migraineurs with and without first-degree family members with migraine. OBJECTIVES: The present cross-sectional study describes differences between familial and sporadic migraine .....
Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
Migraine Genetic Variants Influence Cerebral Blood Flow.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31559635
Headache. 2019 Sep 26. doi: 10.1111/head.13651. [Epub ahead of print]
Association between different lipid parameters and aortic... : Journal of Hypertension
The purpose of our study was to test the associations between lipid parameters and aortic stiffness. Methods: A cross-sectional study was conducted from 2012 to 2017, 603 participants were included: .....
Intravenous Magnesium Sulfate to Treat Acute Headaches in the Emergency Department: A Systematic Review
Source : https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.13648
Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information .....
Does Mindfulness-Based Cognitive Therapy for Migraine Reduce Migraine-Related Disability in People with Episodic and Chronic Migraine? A Phase 2b Pilot Randomized Clinical Trial.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31557329
Headache. 2019 Sep 26. doi: 10.1111/head.13657. [Epub ahead of print]
Discontinuation of Acute Prescription Medication for Migraine: Results From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study
Source : https://headachejournal.onlinelibrary.wiley.com/doi/full/10.1111/head.13642?af=R
Conflict of Interest: Richard B. Lipton, MD, serves on the editorial boards of Neurology and Cephalalgia and as senior advisor to Headache. He has received research support from the NIH. .....
Discontinuation of Acute Prescription Medication for Migraine: Results From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31544244
Headache. 2019 Sep 22. doi: 10.1111/head.13642. [Epub ahead of print]
Characterization of Familial and Sporadic Migraine.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31544229
BACKGROUND: It is unknown whether clinical parameters differ between migraineurs with and without first-degree family members with migraine. OBJECTIVES: The present cross-sectional study describes differences between familial and sporadic migraine .....
Trial of Galcanezumab in Prevention of Episodic Cluster Headache
Source : https://www.nejm.org/doi/full/10.1056/NEJMoa1813440
AbstractBACKGROUNDEpisodic cluster headache is a disabling neurologic disorder that is characterized by daily headache attacks that occur over periods of weeks or months. Galcanezumab, a humanized monoclonal antibody to calcitonin .....
Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: a randomised, phase 3, double-blind, placebo-controlled trial.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31311674
Lancet. 2019 Aug 31;394(10200):737-745. doi: 10.1016/S0140-6736(19)31606-X. Epub 2019 Jul 13. Clinical Trial, Phase III; Multicenter Study; Randomized Controlled Trial
OnabotulinumtoxinA Wear‐off Phenomenon in the Treatment of Chronic Migraine
Source : https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.13638
ObjectiveTo evaluate the frequency and features of onabotulinumtoxinA (onabotA) wear‐off in chronic migraine (CM).
Early Life Stress in Adolescent Migraine and the Mediational Influence of Symptoms of Depression and Anxiety in a Canadian Cohort.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31524287
OBJECTIVE: This study sought to examine the association between early life stressors and adolescent headache in the Canadian population, and the potential mediating influence of symptoms of depression and anxiety. .....
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A Brief Examination Of Cannabinoid Hyperemesis Syndrome
Source : https://protect-us.mimecast.com/s/KqK7ClYvpnu2KJlPnI90Vog?domain=thefreshtoast.com.
Activation of neurological cannabinoid receptors can aid in preventing nausea and vomiting, particularly so in patients undergoing chemotherapy. Considering the usual effects of THC and other cannabinoids on receptors in .....
It's not just a pain in the head-facial pain can be a symptom of headaches too
Source : https://medicalxpress.com/news/2019-08-pain-headfacial-symptom-headaches.html
A new study finds that up to 10 percent of people with headaches also have facial pain. The study is published in the August 21, 2019, online issue of Neurology, .....
Migraines linked to higher risk of dementia
Source : https://medicalxpress.com/news/2019-09-migraines-linked-higher-dementia.html
September 5, 2019 , Wiley Dementia is the most common neurological disease in older adults, whereas headaches, including migraines, are the most common neurological disorder across all ages. In a .....
Anxiety Sensitivity as a Risk Indicator for Anxiety, Depression, and Headache Severity in Women With Migraine
Source : https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/head.13568
AbstractObjectiveThe primary aim of this exploratory study was to assess the relationship between anxiety sensitivity and emotional disorders, migraine characteristics, and migraine‐related fear and avoidance behaviors in women with probable .....
Migraine and the risk of all-cause dementia, Alzheimer's disease, and vascular dementia: A prospective cohort study in community-dwelling older adults.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31486140
OBJECTIVES: Dementia is the most common neurological disease in older adults; headaches, including migraines, are the most common neurological disorder across all ages. The objective of this study was to .....
The Impact of Shift Work on Migraine: A Case Series and Narrative Review.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31469410
OBJECTIVE: We present a case report of 2 migraine patients engaged in shift work, followed by a narrative review, to assess whether shift work influences headache-related disability and chronification of .....
Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31471907
Headache. 2019 Aug 31. doi: 10.1111/head.13618. [Epub ahead of print]
Lamotrigine in the Prevention of Migraine With Aura: A Narrative Review.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31468532
BACKGROUND: Lamotrigine is not recommended in the prevention of migraine in general but some reports suggest that it might be effective for treating specifically migraine with aura (MA). This review .....
It's not just a pain in the head-facial pain can be a symptom of headaches too
Source : https://medicalxpress.com/news/2019-08-pain-headfacial-symptom-headaches.html
A new study finds that up to 10 percent of people with headaches also have facial pain. The study is published in the August 21, 2019, online issue of Neurology, .....
Shortcomings and missed potentials in the management of migraine patients - experiences from a specialized tertiary care center
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1034-8
Migraine is a common and severely disabling neurological disorder affecting millions of patients in Europe. Despite the availability of evidence-based national and international guidelines, the management of migraine patients often .....
The endocannabinoid system in migraine: from bench to... : Current Opinion in Neurology
of migraine but their efficacy and tolerability are controversial. Recent findings Cannabinoids modulate functions and activity of signaling pathways that have a key role in pain control.
Structural changes of cerebellum and brainstem in migraine without aura
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1045-5
Increasing evidence has suggested that the cerebellum is associated with pain and migraine. In addition, the descending pain system of the brainstem is the major site of trigeminal pain processing .....
Diagnosis in 2.127 seconds: Solving a years-long vomiting mystery using AI, research and brain power
2.127 seconds. That's how long it took mediKanren to find 347 possible treatments for nausea. 2.127 seconds that helped bring relief to a young woman who has been throwing up .....
The potential role of serum vitamin D level in migraine headache: a ca | JPR
Mona Hussein, 1 Wael Fathy, 2 Rehab M Abd Elkareem 3 1Department of Neurology, Beni-Suef University, Beni-Suef, Egypt; 2Department of Anaesthesia and Pain Management, Beni-Suef University, Beni-Suef, Egypt; 3Department of .....
Unmet Acute Treatment Needs From the 2017 Migraine in America Symptoms and Treatment Study.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31410844
Headache. 2019 Aug 13. doi: 10.1111/head.13588. [Epub ahead of print]
Common visual disturbances encountered in primary headache disorders
Source : https://www.aao.org/editors-choice/common-visual-disturbances-encountered-in-primary-
Neuro-Ophthalmology/Orbit This paper describes ophthalmic symptoms of primary headache disorders that typically prompt patients to present for neuro-ophthalmic evaluation. The authors identified published literature by searching PubMed for the following .....
The Association Between Low-Density Lipoprotein Cholesterol and Incident Atherosclerotic Cardiovascular Disease in Older Adults: Results From the National Institutes of Health Pooled Cohorts.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31411740
BACKGROUND/OBJECTIVES: Elevated low-density lipoprotein cholesterol (LDL-C) in early adulthood is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). The strength of the association between LDL-C and ASCVD among older .....
Life With Migraine: Effects on Relationships, Career, and Finances From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31407321
Headache. 2019 Aug 12. doi: 10.1111/head.13613. [Epub ahead of print]
Practice guideline update summary: Acute treatment of migraine in children and adolescents
Source : https://n.neurology.org/content/early/2019/08/13/WNL.0000000000008095
Objective To provide evidence-based recommendations for the acute symptomatic treatment of children and adolescents with migraine. Methods We performed a systematic review of the literature and rated risk of bias .....
Nerve-releasing surgery eases migraines for some
Source : http://news.vumc.org/2019/08/07/nerve-releasing-surgery-eases-migraines-for-some/
Clarksville resident Hope Dyer remembers the day she looked out a window, saw it was raining and immediately began crying. She realized it was the first time in more than .....
Drinking 3 or More Caffeinated Beverages Linked to Higher Odds of Migraine, Study Says
There is widespread anecdotal belief that caffeine can cause migraines or ease them once they've begun, although there is little scientific evidence to back that up. A new study released .....
Individualization of Migraine Prevention: A Randomized Controlled Trial of Psychophysical-based Prediction of Duloxetine Efficacy.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31241488
OBJECTIVE: Finding an effective preventive agent for the individual migraineur is often long and frustrating. An individual-specific, efficacy-predicting tool would be invaluable in directing, shortening, and improving this process. As .....
New data indicate rise in opioid use for migraine treatment
Source : https://www.sciencedaily.com/releases/2019/08/190807144357.htm
An increasing number of Americans are using opioids to treat their migraine headaches, despite the fact that opioids are not the recommended first-line therapy for migraine in most cases. That's .....
_6e98296023b34dfabc133638c1ef5d32-620x480.jpg "Nerve-releasing surgery relieves chronic migraine headaches for some patients")
Nerve-releasing surgery relieves chronic migraine headaches for some patients
Clarksville resident Hope Dyer remembers the day she looked out a window, saw it was raining and immediately began crying. She realized it was the first time in more than .....
Real-world effectiveness of onabotulinumtoxinA treatment for the prevention of headaches in adults with chronic migraine in Australia: a retrospective study
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1030-z
OnabotulinumtoxinA (BOTOX®, Allergan plc, Dublin, Ireland) is approved for the preventive treatment of headaches in adult patients with chronic migraine (CM) in Australia by the country's reimbursement mechanism for medicines, .....
Aura and Stroke: relationship and what we have learnt from preclinical models
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1016-x
Population-based studies have highlighted a close relationship between migraine and stroke. Migraine, especially with aura, is a risk factor for both ischemic and hemorrhagic stroke. Interestingly, stroke risk is highest .....
Women with Migraine Face Greater Pregnancy-Related Adverse... : Neurology Today
Article In Brief In an observational study, researchers found migraine is a risk factor for pregnancy-associated hypertension disorders, including preeclampsia/eclampsia, and miscarriage. Researchers in Denmark found that pregnant women with .....
Anxiety Sensitivity as a Risk Indicator for Anxiety, Depression, and Headache Severity in Women With Migraine.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31166015
Headache. 2019 Jun 5. doi: 10.1111/head.13568. [Epub ahead of print]
Comparison of Thrombocyte Count Between Pediatric Patients With Migraine or Tension-Type Headache: A Retrospective Cohort Study - Aviv Benedick, Avraham Zeharia, Tal Eidlitz Markus,
Source : https://journals.sagepub.com/doi/abs/10.1177/0883073819862738
Hypercoagulability may explain the increased risk of thromboembolic cerebrovascular events in patients with migraine. Thrombocytes play a crucial part in the coagulation process, and some studies have demonstrated hyperaggregation of .....
Neuro-Ophthalmic Symptoms of Primary Headache Disorders: Why the Patient With Headache May Present to Neuro-Ophthalmology.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31022065
BACKGROUND: Primary headache disorders can cause many ophthalmic symptoms that lead many patients to present for neuro-ophthalmic evaluation. Neuro-ophthalmologists frequently encounter these patients in clinical practice.
Comparison of Thrombocyte Count Between Pediatric Patients With Migraine or Tension-Type Headache: A Retrospective Cohort Study. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31319753
J Child Neurol. 2019 Jul 18:883073819862738. doi: 10.1177/0883073819862738. [Epub ahead of print]
Relationship of Migraine and Tension-Type Headache With Hypothyroidism: A Literature Review. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31310335
Headache. 2019 Jul 16. doi: 10.1111/head.13600. [Epub ahead of print] Review
Researchers Suggest Early Female Puberty May Be 'Big Bang Theory' For Migraine
Source : https://www.wvxu.org/post/researchers-suggest-early-female-puberty-may-be-big-bang-theory-migraine
A new study suggests girls who reach puberty at earlier ages may be at greater risk for migraine headaches. Vincent Martin, M.D., with UC's College of Medicine presented the findings .....
Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine
Studies have demonstrated that a standard oral formulation of rimegepant can effectively treat acute migraine, leaving researchers to wonder if a novel orally disintegrating tablet might also deliver relief. To .....
Anxiety Sensitivity as a Risk Indicator for Anxiety, Depression, and Headache Severity in Women With Migraine. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31166015
Headache. 2019 Jun 5. doi: 10.1111/head.13568. [Epub ahead of print]
Effects of MTHFR C677T and A1298C Polymorphisms on Migraine Susceptibility: A Meta-Analysis of 26 Studies. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31045246
Headache. 2019 Jun;59(6):891-905. doi: 10.1111/head.13540. Epub 2019 May 2.
Studies explore treatments to prevent cluster headaches, quell...
(Reuters Health) - Two drug trials may promise some relief for people who suffer migraine headaches as well as those who have cluster headaches, a rare but intensely painful type .....
Migraine increases the risk of complications during pregnancy and childbirth
Source : https://www.sciencedaily.com/releases/2019/06/190626125111.htm
Pregnant women with migraine have an increased risk of miscarriage, caesarean sections and giving birth to a child with low birth weight. This is shown by a comprehensive register-based study. .....
Pregnancy, Birth, Neonatal, and Postnatal Neurological Outcomes After Pregnancy With Migraine
Source : https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.13536
AbstractBackgroundPrevalence of migraine is high during the reproductive age. Although migraine often improves during pregnancy, the risk of adverse pregnancy, birth, neonatal, and neurological outcomes in mother and offspring remains .....
Relieving two headaches with one process
Source : https://news.wisc.edu/relieving-two-headaches-with-one-process/
With a new method to synthesize a popular pain-relieving medication from plants rather than fossil fuels, researchers at the Great Lakes Bioenergy Research Center have found a way to relieve .....
Evaluating the Psychometric Properties of the Migraine Functional Impact Questionnaire (MFIQ)
Source : https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.13569
AbstractBackgroundMigraine is a chronic neurologic disease that can be associated with significant migraine‐related impact, disability, and burden. Patient‐reported outcome measures (PRO) are included in clinical trials of migraine interventions to .....
Auditory brainstem function in women with vestibular migraine: a controlled study
Source : https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1368-5
Vestibular migraine (VM) has been recognized as a diagnostic entity over the past three decades. It affects up to 1% of the general population and 7% of patients seen in .....
Optimising migraine treatment: from drug-drug interactions to personalized medicine
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1010-3
Migraine is the most disabling and expensive chronic disorders, the etiology of which is still not fully known. The neuronal systems, (glutammatergic, dopaminergic, serotoninergic and GABA-ergic) whose functionality is partly .....
Study: Young adults with food insecurity have higher migraine risk
A research letter in JAMA Neurology found 23.9% of young adults who were food insecure experienced migraine headaches, compared with 13.6% of those who were not food insecure, and that .....
Auditory brainstem function in women with vestibular migraine: a controlled study
Source : https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1368-5
Vestibular migraine (VM) has been recognized as a diagnostic entity over the past three decades. It affects up to 1% of the general population and 7% of patients seen in .....
Endogenous Na , K -ATPase inhibitors and CSF [Na ] contribute to migraine formation
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218041
There is strong evidence that neuronal hyper-excitability underlies migraine, and may or may not be preceded by cortical spreading depression. However, the mechanisms for cortical spreading depression and/or migraine are .....
Cognitive Decline in Chronic Migraine with Nonsteroid Anti-inflammation Drug Overuse: A Cross-Sectional Study
Source : https://www.hindawi.com/journals/prm/2019/7307198/
Background. Chronic migraine with medication overuse headache (CM-MOH) is the most common type of chronic migraine, and it increases risk of stroke and white matter lesions. These pathologic changes could .....
Early efficacy and late gain in chronic and high‐frequency episodic migraine with OnabotulinumtoxinA - Alpuente - - European Journal of Neurology - Wiley Online Library
Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.14028?af=R
578 patients were recruited and after 24 months outcome data was collected from 100 patients: 84.0% CM and 16.0% HFEM. After 24 months, headache frequency was significantly reduced by 10.5 .....
Anxiety Sensitivity as a Risk Indicator for Anxiety, Depression, and Headache Severity in Women With Migraine. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31166015
Headache. 2019 Jun 5. doi: 10.1111/head.13568. [Epub ahead of print]
Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31135819
JAMA Neurol. 2019 May 28. doi: 10.1001/jamaneurol.2019.0755. [Epub ahead of print]
The biological clock in cluster headache: A review and hypothesis. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31142137?dopt=Abstract
Cephalalgia. 2019 May 29:333102419851815. doi: 10.1177/0333102419851815. [Epub ahead of print]
Pupil Cycle Time Distinguishes Migraineurs From Subjects Without Headache. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31139137?dopt=Abstract
Front Neurol. 2019 May 8;10:478. doi: 10.3389/fneur.2019.00478. eCollection 2019.
Is the presence of neck pain associated with more severe clinical presentation in patients with migraine? A cross-sectional study. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31132869?dopt=Abstract
Cephalalgia. 2019 May 27:333102419854061. doi: 10.1177/0333102419854061. [Epub ahead of print]
FDA approves first treatment for episodic cluster headache that reduces the frequency of attacks
The U.S. Food and Drug Administration today approved Emgality (galcanezumab-gnlm) solution for injection for the treatment of episodic cluster headache in adults. "Emgality provides patients with the first FDA-approved drug .....
Brain changes may be linked to unexplained motor symptoms
Source : https://medicalxpress.com/news/2019-06-brain-linked-unexplained-motor-symptoms.html
A new study finds that people who have movement problems, symptoms that cannot be explained by an underlying disease, may have chemical changes in specific areas of the brain. The .....
Migraine and cluster headache show impaired neurosteroids patterns
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1005-0
Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migraine. Here, we measured .....
Erenumab and galcanezumab in chronic migraine prevention: effects after treatment termination
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1018-8
Monoclonal antibodies (mAbs) targeting the CGRP pathway are safe and efficacious therapies for the prevention of migraine. In this study we assessed the effects of discontinuation of preventive erenumab and .....
Is the presence of neck pain associated with more severe clinical presentation in patients with migraine? A cross-sectional study. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31132869
Cephalalgia. 2019 May 27:333102419854061. doi: 10.1177/0333102419854061. [Epub ahead of print]
Structural and Functional Reorganization of the Brain in Migraine Without Aura. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31133962?dopt=Abstract
Front Neurol. 2019 May 7;10:442. doi: 10.3389/fneur.2019.00442. eCollection 2019.
Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31135819?dopt=Abstract
JAMA Neurol. 2019 May 28. doi: 10.1001/jamaneurol.2019.0755. [Epub ahead of print]
Calcitonin Gene-Related Peptide Causes Migraine-Like Pain in Female But Not Male Rodents
Migraine is a complex condition that causes more disability than all other neurological disorders combined. Characterized by an extreme throbbing headache, increased sensitivity to light, touch, and sound, nausea and .....
Pupil Cycle Time Distinguishes Migraineurs From Subjects Without Headache. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31139137?dopt=Abstract
Front Neurol. 2019 May 8;10:478. doi: 10.3389/fneur.2019.00478. eCollection 2019.
The Clinical Characteristics and Neurophysiological Assessments of the Occipital Cortex in Visual Snow Syndrome With or Without Migraine
Source : https://onlinelibrary.wiley.com/doi/10.1111/head.13494
AbstractObjectiveVisual snow syndrome (VS) is mainly characterized by flickering, little dots in both visual fields. The recognition of the clinical entity of VS has been increasing recently. Diagnosis is based .....
Reduced Short‐Latency Afferent Inhibition Indicates Impaired Sensorimotor Integrity During Migraine Attacks
Source : https://www.onlinelibrary.wiley.com/doi/abs/10.1111/head.13554
AbstractBackground and ObjectiveMigraine attacks disrupt sensory information processing and may also disturb sensorimotor integration. This prospective pilot study aimed to assess the sensorimotor integration and inhibitory circuitry in the sensorimotor .....
Improving Relationships Between Neurologists and Patients with Migraine
Neurologists and their patients share a unique relationship. It takes active investment and open communication from both parties in order to achieve effective treatment and get patients the care they .....
Effectiveness of Oxygen and Other Acute Treatments for Cluster Headache: Results From the Cluster Headache Questionnaire, an International Survey
Source : https://onlinelibrary.wiley.com/doi/10.1111/head.13473
AbstractObjectiveTo assess the effectiveness and adverse effects of acute cluster headache medications in a large international sample, including recommended treatments such as oxygen, commonly used medications such as opioids, and .....
Women are less likely than men to be diagnosed with minor stroke: Study encourages doctors to look beyond typical symptoms for stroke
Source : https://www.sciencedaily.com/releases/2019/05/190523143048.htm
Women experiencing a minor stroke or transient ischemic attack (TIA) are less likely to be diagnosed with a stroke compared to men -- even though they describe similar symptoms in .....
The Role of Melatonin in the Treatment of Primary Headache Disorders
Source : http://onlinelibrary.wiley.com/doi/10.1111/head.12862/abstract
AbstractObjectiveTo provide a summary of knowledge about the use of melatonin in the treatment of primary headache disorders.
Is aerobic exercise an effective treatment strategy for patients with migraine? - On Medicine
Aerobic exercise has the potential to mitigate symptoms of migraine by modulating the pain process in the brain. A recent review published in the Journal of Headache and Pain explored .....
Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking
Source : https://link.springer.com/article/10.1186/s10194-019-0992-1
Raffi Manoukian Hong Sun Silke Miller Di Shi Brian Chan Cen Xu Research article Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of .....
Periodontal inflammation is related to increased serum calcitonin gene-related peptide (CGRP) levels in patients with chronic migraine. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31070784
AbstractBACKGROUND:Recently, a relationship was found between periodontitis and chronic migraine. Calcitonin gene-related peptide (CGRP) is a key element in migraine pathophysiology. However, no information exists of the potential association between .....
Remote Electrical Neuromodulation (REN) Relieves Acute Migraine: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31074005
AbstractOBJECTIVE:To assess the efficacy and safety of a remote electrical neuromodulation (REN) device for the acute treatment of migraine.
Neuropathy May Drive Dry Eye in Migraine Patients
Source : https://eyewire.news/articles/neuropathy-may-drive-dry-eye-in-migraine-patients/
Migraine patients with dry eye are more likely to have symptoms suggestive of neuropathy than dry eye patients who don't have migraines, according to new findings, as reported by Reuters .....
Pregnancy, Birth, Neonatal, and Postnatal Neurological Outcomes After Pregnancy With Migraine
Background.—Prevalence of migraine is high during the reproductive age. Although migraine often improves during pregnancy, the risk of adverse pregnancy, birth, neonatal, and neurological outcomes in mother and offspring remains .....
Episodic and Chronic Migraine in Primary Care
Objective.—To inform migraine care model development by assessing differences between patients with chronic migraine (CM) and episodic migraine (EM) in the current state of treatment, disability, patient satisfaction, and quality .....
New target for chronic pain: Shape of structure that nerve cells use to sense cold
Source : https://www.sciencedaily.com/releases/2019/02/190207142201.htm
People are great at detecting cold temperatures and the cool sensation induced by natural substances like menthol. And while the same protein in nerve cells is responsible for sensing both, .....
High School Start Time and Migraine Frequency in High School Students. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31016722
AbstractOBJECTIVE:To investigate whether later high school start time is associated with lower migraine frequency in high school students with migraine.
Personality traits in migraine and medication-overuse headache: A comparative study. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/31038726
Acta Neurol Scand. 2019 Apr 30. doi: 10.1111/ane.13111. [Epub ahead of print]
Association Between Migraine and Benign Paroxysmal Positional Vertigo Among Adults in South Korea. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/30676633
AbstractIMPORTANCE:Patients with migraine often experience various types of vertigo, and several studies have suggested an epidemiologic and physiologic association of migraine and vertigo with vestibule. However, few researchers have investigated .....
Preliminary Evidence that Melatonin Is not a Biomarker With Children and Adolescents With Episodic Migraine
Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/head.13547
AbstractBackgroundTo date, there have not been reliable biomarkers to identify impending migraine episodes. A prior study in adults with migraine demonstrated a reduction in the urinary metabolic substrate of melatonin .....
Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort
Source : https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-018-0862-2
Medicinal cannabis registries typically report pain as the most common reason for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and headache, as compared .....
Association Between Dry Eye Disease and Migraine Headaches in a Large Population-Based Study. - PubMed - NCBI
Source : https://www.ncbi.nlm.nih.gov/pubmed/30844042
JAMA Ophthalmol. 2019 Mar 7. doi: 10.1001/jamaophthalmol.2019.0170. [Epub ahead of print]
Migraine and Markers of Carotid Atherosclerosis in Middle‐Aged Women: A Cross‐Sectional Study
Source : https://onlinelibrary.wiley.com/doi/full/10.1111/head.13460
AbstractObjectiveThis study evaluated the association between migraine and the markers of carotid artery disease.
Risk of ischaemic stroke in patients with migraine: a longitudinal follow-up study using a national sample cohort in South Korea
Source : https://bmjopen.bmj.com/content/9/4/e027701?rss=1
Objective Accumulating evidence has supported the association between migraine and stroke, but the causative association remains unclear. We aimed to investigate the risks of different types of stroke in patients .....