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Waking Up With Headaches: 6 Types of Wake Up Headaches.

WAKING UP WITH HEADACHES: 6 TYPES OF WAKE UP HEADACHES. @Neuralgroover WAKE UP HEADACHE Do you frequently wake up with a headache? This is a common feature with several types ..... see more

Source : https://virtualheadachespecialist.com/wake-up-headaches-why-you-are-waking-up-with-headaches/

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  • 11 hours 43 min
    This is a good review, it is important to distinguish between waking up with a headache and waking up because of a headache, which can sometimes be more worrisome. Show More
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Calcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects

Migraine is the second largest cause of years lost to disability globally among all diseases, with a worldwide prevalence over 1 billion. Despite the global burden of migraine, few classes ..... see more

Source : https://jnnp.bmj.com/content/early/2021/01/25/jnnp-2020-324674.abstract

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Why Patients Do Not Comply With Headache Diaries?

Background: Headache calendars are part of good clinical practice in headache clinics. However, patients' compliance is rather variable. We aim to identify factors associated with poor compliance. Methods: Consecutive patients ..... see more

Source : https://www.researchsquare.com/article/rs-152653/v1

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  • 11 hours 46 min
    This is a helpful finding, I try to get my patients to keep calendars but it can be difficult.
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Relationship between non-headache symptoms and right to left shunt in episodic migraine. A single-center cross-sectional study,Journal of Clinical Neuroscience - X-MOL

The relationship between right to left shunt (RLS) and non-headache symptoms (NHS) in episodic migraine is unknown. This study aimed to investigate the incidence and classification of RLS in episodic ..... see more

Source : https://www.x-mol.com/paper/1354517570827722752

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  • 11 hours 49 min
    Interesting study, but I wonder if closing PFO are helpful?
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Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients

Background . CircRNAs are noncoding RNA molecules that have recently been described and shown to regulate miRNA functionality. While recent studies have suggested such circRNAs to be associated with pain ..... see more

Source : https://www.hindawi.com/journals/bmri/2020/4710780/

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  • 11 hours 54 min
    Epigenetics will be the future of medicine.
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Headache during SARS‐CoV‐2 infection as an early symptom associated with a more benign course of disease: a case-control study

Carmen Ramos Neurology Department, Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria de La Princesa, Madrid, Spain Headache Unit, Neurology Department, Hospital Universitario de La Princesa and Instituto ..... see more

Source : https://onlinelibrary.wiley.com/doi/10.1111/ene.14718

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  • 11 hours 58 min
    I wonder if these are from the other factors involved or that patients who are more severely effected do not notice the headache, or another theory is that the virus Show More
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Effectiveness of ketogenic diet in treatment of patients with refractory chronic migraine

Background and purpose Ketogenic diet (KD) is based on restriction of carbohydrate intake. Metabolism is forced to obtain energy starting from β-oxidation of fatty acids which, turned into ketone bodies, ..... see more

Source : https://link.springer.com/article/10.1007/s10072-021-05078-5

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  • 12 hours 13 min
    These are very impressive results, days of symptoms improved from 30 to 7.5, as well as migraine duration, would like to see this validated in other studies as well.
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Migraine and handedness

Migraine is a typically unilateral disorder in adulthood; however, the reasons for painful lateralization have been little investigated. The possible influence of manual dominance was suggested. We aimed to investigate ..... see more

Source : https://link.springer.com/article/10.1007/s10072-021-05111-7

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  • 12 hours 27 min
    Interesting study, I am right handed but most of my migraines are on the left!
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Medication Overuse Headache in Chronic Migraine Patients Using Cannabis: A Case-Referent Study

Objective: To examine whether cannabis use predicts medication overuse headache (MOH) in chronic migraine (CM) patients. Methods: Electronic chart review was conducted by combining the terms "chronic migraine", "medication overuse", ..... see more

Source : https://europepmc.org/article/ppr/ppr279684

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  • 12 hours 28 min
    This is an interesting finding since cannabis is sometimes thought as an alternative to using abortives, but this study shows that it can increase the risk of still overusing abortives Show More
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The de novo CACNA1A pathogenic variant Y1384C associated with hemiplegic migraine, early onset cerebellar atrophy and developmental delay leads to a loss of Cav2.1 channel function

CACNA1A pathogenic variants have been linked to several neurological disorders including familial hemiplegic migraine and cerebellar conditions. More recently, de novo variants have been associated with severe early onset developmental ..... see more

Source : https://link.springer.com/article/10.1186/s13041-021-00745-2

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  • 12 hours 32 min
    This is a good article that shows how migraine genes are related to other brain metabolic and other functions.
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Subjective cognitive impairment in patients with transformed migraine and the associated psychological and sleep disturbances

Purpose Migraines are associated with multiple comorbidities like depression, anxiety, poor sleep quality, and subjective cognitive impairment (SCI). This study aimed to evaluate the association of SCI with depression, anxiety, ..... see more

Source : https://link.springer.com/article/10.1007/s11325-021-02308-0

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  • 12 hours 35 min
    Many patients described ongoing cognitive impairments which can make sense with sleep problems also being common in migraine. Mindfulness can be a helpful technique with combating some of these Show More
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A Bidirectional View of Migraine and Diet Relationship | NDT

Parisa Gazerani 1, 2 1Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark; 2Pharmacy, Department of Life Sciences and Health, Faculty of Health Sciences, OsloMet, Oslo, ..... see more

Source : https://doi.org/10.2147/NDT.S282565

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  • 12 hours 41 min
    The relationship between migraine influencing diet choices, this is an interesting phenomenon that needs further exploration.
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Structural and Functional Brain Changes in Migraine

Migraine is a prevalent primary headache disorder and is usually considered as benign. However, structural and functional changes in the brain of individuals with migraine have been reported. High frequency ..... see more

Source : https://link.springer.com/article/10.1007/s40122-021-00240-5

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  • 12 hours 43 min
    Migraine has been always seen as a "benign disorder" but overtime we have seen that there are definite changes in the brain that may lead to long term morbidity. Show More
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Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference

A neuronal dysfunction based on the imbalance between excitatory and inhibitory cortical-subcortical neurotransmission seems at the basis of migraine. Intercritical neuronal abnormal excitability can culminate in the bioelectrical phenomenon of ..... see more

Source : https://www.mdpi.com/2076-3425/11/2/234/htm

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  • 12 hours 48 min
    It will be interesting to see all the places where cGRP is incorporated and plays a role.
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Sex dependent sensitivity to CGRP

Recent studies reported by Dr Greg Dussor (University of Texas, Dallas) at the 2017 American Headache Society meeting in Boston, USA, have opened up an exciting new perspective on CGRP ..... see more

Source : https://www.cgrpforum.org/authors/andrew-f-russo/

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  • 12 hours 51 min
    very interesting, this opens up the field to test cGRP on men more specifically to see if this theory holds true.
Sumanjit Kaur, Amy Gonzales from Doctor Unite Commented on a Post
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Episodic and Chronic Migraine Treatment during the COVID-19 Pandemic

COVID-19 has made it necessary for clinicians to adapt how they diagnose, treat, and manage patients with chronic diseases, including migraine. With lockdowns and patients concerns about leaving their homes, telemedicine and the availability of efficacious self-administered therapies, such as subcutaneous prophylactic CGRPs, have facilitated the continued care of migraineurs.

Initiation of prophylactic CGRPs is typically prescribed for migraineurs with 4+ migraine days per month who have failed 2+ oral therapies However, since the COVID-19 pandemic, migraine treatment decisions have likely changed due to Botox injection cancellations, potential SARS-CoV-2 infections, increased anxiety or headache triggers, and putative links between the use of certain drugs, such as angiotensin‐converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs), and increased COVID-19 infection risk1. (I would delete this portion because it relates to hospitalized COVID-19 patients)

How has the COVID-19 pandemic impacted your prescribing decisions regarding the initiation of prophylactic CGRP therapy in episodic and chronic migraine patients? What are the factors that contribute to treatment selection during the pandemic?

1 https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-acc-aha-statement-addresses-concerns-re-using-raas-antagonists-in-covid-19
 

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  • 1 week 1 day
    I am prescribing CGRP inhibitors , pandemic has not effected my decision, preauthorisation process is the one that takes time..
  • from Doctor Unite 1 week 1 day
    Some of the factors that contribute to treatment selection would be the patients history of using previous medications for migraines, effectiveness of switching to a new medication, and mode of Show More
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Somatosensory Gating Responses Are Associated with Prognosis in Patients with Migraine

Sensory gating, a habituation-related but more basic protective mechanism against brain sensory overload, is altered in patients with migraine and linked to headache severity. This study investigated whether somatosensory (SI) ..... see more

Source : https://www.mdpi.com/2076-3425/11/2/166

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A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine

Migraine is a common neurovascular condition. This disorder has a complex genetic background. Several single-nucleotide polymorphisms (SNPs) or mutations within genes regulating glutamatergic neurotransmission, cortical excitability, ion channels, and solute ..... see more

Source : https://link.springer.com/article/10.1007/s12031-020-01788-1

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The impact of Pain-related emotions on migraine

Migraine is one of the most common headache disorders, with a worldwide prevalence ranging from 5 to 12%. The World Health Organization (WHO) has recognized migraine as an urgent public ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804193/

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  • 4 weeks
    I think anxiety and fear of pain play a great role in the prognosis of these patients long term. Many patients describe that the anxiety of their next attack is Show More