All Quizzes > The burden of gMG: how does it show up in your practice?

See life with gMG through your patient's lens

Explore patient-reported symptom burden and current insights into underlying disease mechanisms.

gMG=generalized myasthenia gravis.

  • The burden of gMG: how does it show up in your practice?
    Q1.

    Patients with gMG can experience fluctuating weakness across critical muscle groups. Which muscle groups are affected?1-4

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    Correct Answer: E

    gMG=generalized myasthenia gravis.

    References: 1. Gilhus NE et al. Nat Rev Neurol. 2016;12(5):259-268. doi:10.1038/nrneurol.2016.44 2. Dewilde S et al. BMJ Open. 2023;13(1):e066445. doi:10.1136/bmjopen-2022-066445 3. Twork S et al. Health Qual Life Outcomes. 2010;8:129. doi:10.1186/1477-7525-8-129 4. Gilhus NE. N Engl J Med. 2016;375(26):2570-2581. doi:10.1056/NEJMra1602678

  • The burden of gMG: how does it show up in your practice?
    Q2.

    MG symptoms, like muscle weakness or blurred vision, can occur unpredictably and can cause considerable challenges, even when symptoms are mild. What percentage of patients with MG reported losing some personal independence, such as driving, shopping, and running errands?1

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    Correct Answer: C

    *Data from MyRealWorld-MG, a prospective, digital, multinational observational study of 2,074 adults with myasthenia gravis across 9 countries, assessing patient-reported burden versus the general population at baseline.1
    MG=myasthenia gravis.

    Reference: 1. Dewilde S et al. Adv Ther. 2024;41(1):271-291. doi:10.1007/s12325-023-02704-w

  • The burden of gMG: how does it show up in your practice?
    Q3.

    ~85% of patients who develop gMG often initially present with which kind of symptoms?1

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    Correct Answer: C

    gMG=generalized myasthenia gravis.

    Reference: 1. Grob D et al. Muscle Nerve. 2008;37(2):141-149. doi:10.1002/mus.20950

  • The burden of gMG: how does it show up in your practice?
    Q4.

    IgG autoantibodies are a key driver of gMG and can target multiple components of the NMJ, including1-3:

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    Correct Answer: D

    AChR=acetylcholine receptor; gMG=generalized myasthenia gravis; IgG=immunoglobulin G; LRP4=low-density lipoprotein receptor-related protein 4; MuSK=muscle-specific tyrosine kinase; NMJ=neuromuscular junction.

    References: 1. Gilhus NE. N Engl J Med. 2016;375(26):2570-2581. doi:10.1056/NEJMra1602678 2. Rødgaard A et al. Clin Exp Immunol. 1987;67(1):82-88. 3. Behin A, Le Panse R. J Neuromuscul Dis. 2018;5(3):265-277. doi:10.3233/JND-170294

  • The burden of gMG: how does it show up in your practice?
    Q5.

    What percentage of patients with gMG are considered triple seronegative, meaning they have no detectable autoantibodies?1,2

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    Correct Answer: B

    gMG=generalized myasthenia gravis.

    References: 1. Gilhus NE. N Engl J Med. 2016;375(26):2570-2581. doi:10.1056/NEJMra1602678 2. Wolfe GI et al. J Neurol Sci. 2021;430:118074. doi:10.1016/j.jns.2021.118074

  • The burden of gMG: how does it show up in your practice?
    Q6.

    gMG may lead to productivity loss at work. On average, patients with MG experience how many sick days per year?1*

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    Correct Answer: A

    *Data from MyRealWorld-MG (December 2019-July 2023), a multinational observational study of 2,424 adult MG patients across 10 countries, which was aimed at assessing productivity loss by symptom severity. 1,049 of the patients studied reported their MG-ADL score as well as data on sick leave and/or their need for a caregiver. Inclusion required patients to be aged ≥18; those over 65 were excluded from productivity analyses. Patients self-reported their diagnosis in the MyRealWorld-MG smartphone application.1
    MG=myasthenia gravis; MG-ADL=Myasthenia Gravis Activities of Daily Living.

    Reference: 1. Dewilde S et al. Front Public Health. 2025;13:1538789. doi:10.3389/fpubh.2025.1538789

  • The burden of gMG: how does it show up in your practice?
    Q7.

    A survey showed what percentage of patients (n=28) still experienced muscle fatigability despite being on current commonly used treatments?1*

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    Correct Answer: C

    *Data collected from a qualitative, cross-sectional, non-interventional study in 28 people who reported receiving at least one treatment for gMG, including AChEIs, steroids, or NSISTs. Eligible participants were US residents, ≥18 years old, and comfortable reading and communicating in English. Study excluded people with only ocular disease to better understand the breadth of MG symptoms that affect all muscle groups.1
    AChEI=acetylcholinesterase inhibitor; AChR=acetylcholine receptor; gMG=generalized myasthenia gravis; MG=myasthenia gravis; NSIST=nonsteroidal immunosuppressive therapy.

    Reference: 1. Jackson K et al. Neurol Ther. 2023;12(1):107-128. doi:10.1007/s40120-022-00408-x